Effects of BMP7 Produced by Group 2 Innate Lymphoid Cells on Adipogenesis

International Immunology
Yurina MiyajimaKazuyo Moro

Abstract

Group 2 innate lymphoid cells (ILC2s) are type 2 cytokine-producing cells that have important roles in helminth infection and allergic inflammation. ILC2s are tissue resident cells, and their phenotypes and roles are regulated by tissue-specific environmental factors. While the role of ILC2s in the lung, intestine, and bone marrow has been elucidated in many studies, their role in adipose tissues is still unclear. Here, we report on the role of ILC2-derived bone morphogenic protein 7 (BMP7) in adipocyte differentiation and lipid accumulation. Co-culture of fat-derived ILC2s with pluripotent mesenchymal C3H10T1/2 cells and committed white preadipocyte 3T3-L1 cells resulted in their differentiation to adipocytes and induced lipid accumulation. Co-culture experiments using BMP7-deficient ILC2s revealed that BMP7, produced by ILC2s, induces differentiation into brown adipocytes. Our results demonstrate that BMP7, produced by ILC2s, affects adipocyte differentiation, particularly in brown adipocytes.

References

Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
Jun 7, 2002·The Biochemical Journal·Gilles CroissandeauMajambu Mbikay
Jan 17, 2003·The Journal of Biological Chemistry·Carine ChaveySophie Tartare-Deckert
May 6, 2005·Cytokine & Growth Factor Reviews·Satoshi Kishigami, Yuji Mishina
Oct 7, 2008·Cell·Matthew S RodehefferJeffrey M Friedman
Feb 28, 2009·The International Journal of Developmental Biology·Vasiliki ZouvelouDaniel Graf
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Haiyan HuangQi-Qun Tang
May 8, 2010·Science·Jeff Ishibashi, Patrick Seale
Jun 1, 2010·Journal of Cellular Biochemistry·Andrea ArmaniMassimiliano Caprio
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tim J SchulzYu-Hua Tseng
Dec 6, 2011·Journal of Lipid Research·William P CawthornOrmond A MacDougald
Mar 20, 2012·Analytical Biochemistry·Katja ZebischMatthias Brandsch
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Feb 26, 2013·Nature Cell Biology·Ryan Berry, Matthew S Rodeheffer
Jun 29, 2013·The Biochemical Journal·Tim J Schulz, Yu-Hua Tseng
Oct 23, 2013·Nature Reviews. Endocrinology·Alexander Bartelt, Joerg Heeren
Mar 5, 2014·Cold Spring Harbor Perspectives in Medicine·Guillermo Rivera-GonzalezValerie Horsley
Jan 27, 2015·Nature Immunology·Michelle L RobinetteUNKNOWN Immunological Genome Consortium
May 1, 2015·Nature Protocols·Kazuyo MoroShigeo Koyasu
Aug 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliDavid Artis
Oct 17, 2015·Science·Georg GasteigerAlexander Y Rudensky
Dec 18, 2015·Nature·Jakob von MoltkeRichard M Locksley
May 8, 2018·The Journal of Experimental Medicine·Satoshi KogaKazuyo Moro
Jul 4, 2019·Cell Reports·Takaharu SasakiShigeo Koyasu

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Citations

Dec 8, 2020·Frontiers in Cardiovascular Medicine·Ibrahim AlZaimAhmed F El-Yazbi
Oct 29, 2021·The Journal of Experimental Medicine·Yuki HikichiKazuyo Moro

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