Effects of Body Mass Index on the Lipid Profile and Biomarkers of Inflammation and a Fibrinolytic and Prothrombotic State

Journal of Atherosclerosis and Thrombosis
Esteban Orenes-PiñeroFrancisco Marín

Abstract

Both an overweight status and obesity are associated with high cardiovascular morbidity and mortality. The aim of this study was to examine the effects of obesity on different underlying mechanisms, i.e. inflammation, fibrinolysis and a prothrombotic state, in a young high-risk population in the Mediterranean area. The study population included 237 subjects (median age: 44 years). We recorded the presence of cardiovascular risk factors and premature ischaemic heart disease and performed weight stratification using the body mass index (BMI) according to the established World Health Organization (WHO) criteria. We also measured the serum/plasma lipid, fibrinogen, D-dimer, von Willebrand factor, tissue plasminogen activator antigen (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) and high-sensitivity C-reactive protein (CRP-hs) levels in samples of peripheral blood. The subjects with premature ischaemic heart disease and hypertension had higher BMI values (p<0.01), and the subjects with an increased weight showed an unadjusted detrimental lipid profile, with a proinflammatory, prothrombotic state and abnormal fibrinolytic parameters. According to a multivariate analysis, the HDL-cholesterol (r(2)=0.176; p<0.001), t-PA ant...Continue Reading

References

Jun 15, 1993·Annals of Internal Medicine·E Ernst, K L Resch
Dec 8, 1998·American Heart Journal·V RoldánF Sogorb
Feb 16, 1999·Revista española de cardiología·F Marín OrtuñoF Sogorb Garri
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G MarescaG Di Minno
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M Cesari, G P Rossi
Sep 14, 1999·The American Journal of Medicine·N Abate
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
May 4, 2000·The Medical Clinics of North America·M T Sheehan, M D Jensen
Feb 13, 2001·The American Journal of Cardiology·A HoffmeisterW Koenig
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 4, 2001·JAMA : the Journal of the American Medical Association·M A AlbertUNKNOWN PRINCE Investigators
Nov 15, 2001·Obesity Research·P T JamesM Shayeghi
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Feb 25, 2003·Journal of the American College of Cardiology·Jason H ColeWilliam S Weintraub
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Sonia S Anand
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Sep 5, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Loukianos S RallidisDimitrios T Kremastinos

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Citations

Aug 11, 2017·Journal of Atherosclerosis and Thrombosis·Yutaka Hasegawa, Yasushi Ishigaki
Jun 9, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Mohammed Elimam Ahamed MohammedMustafa Musa
Feb 24, 2016·Journal of Atherosclerosis and Thrombosis·Marco Matteo CicconePaola Giordano
Mar 8, 2018·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Adham do Amaral E CastroMaria Angela M Barreiros
May 23, 2018·Journal of Obesity·Noor Shafina Mohd NorHapizah Mohd Nawawi
Jul 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Barbara S TaylorMatthew S Freiberg

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