Effects of bolus somatostatin in preventing pancreatitis after endoscopic pancreatography: results of a randomized study

Gastrointestinal Endoscopy
J M BordasJ Terés

Abstract

Pancreatitis is a potential problem in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Natural somatostatin reduces pancreatic secretion and has been administered in acute pancreatitis. To establish whether an injection of a single "bolus" of natural somatostatin is useful in preventing pancreatic reactions after endoscopic pancreatography, a randomized study was carried out in 160 patients undergoing pancreatography, associated or not, with endoscopic sphincterotomy. Pancreatitis was considered to be present when there was the simultaneous appearance of serum amylase above 600 IU/mL and serum lipase above 200 IU, upper abdominal pain with tenderness, nausea and/or vomiting, and associated ileus, not completely resolved within 18 hours after the procedure and prolonging hospital stay. The incidence of pancreatitis (10% vs. 2.5%, p < 0.05) was higher in the placebo group than in the somatostatin-treated group. The difference in frequency of pancreatitis was statistically significant (18% vs 0%, p < 0.05) in the ERCP plus sphincterotomy subgroup but not significant (6% versus 4%) in the ERCP subgroup. These results suggest that the administration of a single bolus injection of natural somatostatin just ...Continue Reading

Citations

Mar 14, 2007·Journal of Gastroenterology·Ghalib H AbidBasil J Ammori
Jun 3, 2004·Gastrointestinal Endoscopy·Martin L Freeman, Nalini M Guda
Jul 18, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R Madhotra, M Lombard
Dec 10, 1999·The New England Journal of Medicine·W R Brugge, J Van Dam
Oct 7, 2006·Current Opinion in Gastroenterology·H G Hotz, H A Reber
Oct 13, 2006·Current Opinion in Gastroenterology·J N Shah, M L Kochman
Dec 31, 2008·Journal of the Chinese Medical Association : JCMA·Hoi-Hung ChanE-Ming Wang
Oct 24, 2006·Gastrointestinal Endoscopy·Konstantinos C ThomopoulosVassiliki N Nikolopoulou
Jan 8, 2000·Gastrointestinal Endoscopy·A AndriulliG De Maio
May 6, 1999·Gastrointestinal Endoscopy·R A Kozarek
Mar 30, 2002·Gastrointestinal Endoscopy·Thomas RabensteinH Thomas Schneider
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Dimitrios ArvanitidisPanagiotis Kostopoulos
Nov 15, 2020·Current Gastroenterology Reports·Nikhil R Thiruvengadam, Michael L Kochman
Mar 20, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Guiliang WangXianzhong Xiao

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