Effects of bone marrow-derived mesenchymal stem cells transplanted via the portal vein or tail vein on liver injury in rats with liver cirrhosis

Experimental and Therapeutic Medicine
Ying-Ming SongXiao-Yan Wang

Abstract

The aim of the present study was to compare the effects of bone marrow-derived mesenchymal stem cells (BMSCs) transplanted via the portal vein or tail vein on liver injury in rats with liver cirrhosis. BMSCs were isolated from rat bone marrow and labeled with green fluorescent protein (GFP). Then, the labeled BMSCs were injected into rats with liver injury via the portal vein or tail vein. Two weeks after transplantation, three rats in each group were sacrificed to test the distribution of GFP in the liver and the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin. Six weeks later, the remaining rats were sacrificed, and serum ALT, AST, albumin, hyaluronic acid (HA), laminin (LN) and procollagen type III (PC-III) levels were measured. The expression of albumin in the liver was analyzed by immunohistochemistry. Two weeks after BMSC transplantation, GFP-positive cells were detected in the livers of rats with BMSCs transplanted via the portal vein and tail vein. Compared with pre-transplantation levels, the ALT levels of the groups with BMSC transplantation via the portal vein and tail vein were significantly decreased after two and six weeks of BMSC transplantation (P<0.05), whereas the A...Continue Reading

References

Jul 9, 2004·Biochemical and Biophysical Research Communications·P Ping WangJohn M Luk
Aug 1, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A GasbarriniC Di Campli
Jan 8, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyohito YagiHajime Ohgushi
Mar 21, 2008·Digestive Diseases and Sciences·Lijun ShiHulun Li
May 29, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Liang LiangTingbo Liang
Dec 23, 2009·Stem Cells and Development·Evangelos DalakasJohn N Plevris
Jan 26, 2010·Magnetic Resonance Imaging·Bin ZhouXiao-Chun Meng
Jan 10, 2012·Journal of Biomedicine & Biotechnology·Maria Ausiliatrice PuglisiAntonio Gasbarrini
Aug 12, 2014·International Journal of Molecular Medicine·Lihua SunYuexin Zhang
Sep 5, 2014·Experimental and Therapeutic Medicine·Shufang YuanYuexin Zhang

❮ Previous
Next ❯

Citations

Aug 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZhaoHai-Xiang Yu
Feb 9, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Kwangmin KimKeum Seok Bae

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Jun TaoRonghua Liu
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Weimin CaiRonghua Liu
Nihon rinsho. Japanese journal of clinical medicine
Y Miura
Nihon rinsho. Japanese journal of clinical medicine
Y Miura
© 2021 Meta ULC. All rights reserved