Effects of bone marrow stromal cell injection in an experimental glaucoma model

Biochemical and Biophysical Research Communications
Saiyuu YuNagahisa Yoshimura

Abstract

We investigated if bone marrow stromal cells (BMSCs) transplanted into the vitreous body of a glaucoma model eye could be integrated in the host retina and also whether they could rescue the retinal ganglion cells (RGCs) from death induced by the elevated intraocular pressure. Glaucoma was induced in the right eye of adult Wistar rats by ligating the episcleral veins. The GFP-expressing BMSCs (GFP-BMSCs) were injected into the vitreous body of both the control and the glaucomatous eyes. After transplantation, GFP-BMSCs were mostly present along with the inner limiting membrane and only a few cells were integrated into the ganglion cell layer. At 2 or 4 weeks after transplantation, GFP-BMSCs were observed to express various trophic factors. The BMSCs injected glaucoma model eyes showed less reduction in the number of RGCs compared to the glaucomatous eyes with PBS injection. This study suggests that BMSC transplantation may be worthy as a neuroprotective tool to treat glaucoma.

References

May 1, 1995·Australian and New Zealand Journal of Ophthalmology·H A Quigley
Sep 1, 1995·Experimental Eye Research·S R ShareefS C Sharma
Sep 24, 1998·Experimental Brain Research·I B KimM H Chun
Jan 27, 1999·Progress in Retinal and Eye Research·H A Quigley
Feb 23, 1999·The American Journal of Pathology·E LabouyrieJ P Merlio
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·A H NeufeldB Becker
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Samantha J Van HoffelenDonald S Sakaguchi
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Yan GuoDennis W Rickman
Sep 26, 2003·Investigative Ophthalmology & Visual Science·Keith R G MartinWilliam W Hauswirth
Dec 11, 2003·Molecular and Cellular Neurosciences·Przemyslaw S SapiehaAdriana Di Polo
Feb 20, 2004·Transactions of the American Ophthalmological Society·Joseph CaprioliJacky M K Kwong
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takaya MiyawakiTeruyo Tanabe
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Stefan ArnholdUlrich Schraermeyer
Mar 15, 2005·Current Eye Research·Frank SchuettaufJean Bennett
Aug 2, 2005·Neuroreport·Keizo MinaminoSusumu Ikehara
Jan 1, 2016·JAMA Ophthalmology·Eve J Higginbotham, Lenora A Higginbotham

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Citations

Dec 17, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Na LiJia-qin Yuan
Nov 12, 2009·Regenerative Medicine·Natalie D Bull, Keith R Martin
Oct 21, 2010·Current Eye Research·Aaron W Joe, Kevin Gregory-Evans
Mar 11, 2015·Stem Cell Research·Ben MeadBen A Scheven
Jul 22, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Annegret Dahlmann-NoorPeng Tee Khaw
Aug 6, 2010·Experimental Eye Research·Thomas V JohnsonKeith R Martin
Jun 2, 2007·British Journal of Haematology·James M FoxJim Middleton
Jul 23, 2015·Neural Regeneration Research·Jeffrey N WeissAlexis Malkin
Apr 17, 2015·Neural Regeneration Research·Ben Mead, Ben A Scheven
Dec 10, 2015·Stem Cells International·Louise A Mesentier-LouroMarcelo F Santiago
Sep 4, 2012·Current Opinion in Pharmacology·Thomas V Johnson, Keith R Martin
Jun 12, 2016·Pharmacology & Therapeutics·M I G Lopez SanchezI A Trounce
Jan 14, 2017·Eye·T Z Khatib, K R Martin
Jan 24, 2017·Progress in Retinal and Eye Research·Melissa K JonesShaomei Wang
Jun 16, 2009·Cell Transplantation·Tom K KuoOscar K Lee
Aug 20, 2010·Cell Transplantation·Camila Zaverucha-do-ValleRosalia Mendez-Otero
Apr 29, 2014·World Journal of Stem Cells·Tsz Kin NgHerman S Cheung
Jun 15, 2018·Clinical & Experimental Ophthalmology·Chelsea GuymerRobert J Casson
Mar 5, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Reas S KhanKenneth S Shindler
Feb 1, 2012·Molecular and Cellular Biochemistry·Neeru JindalAkshay Anand
Sep 3, 2019·Current Eye Research·Tasneem Z Khatib, Keith R Martin
Jun 13, 2015·The Open Ophthalmology Journal·Kolko M

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