Effects of bone remodelling on calcium mass transfer during haemodialysis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Cristina KarohlRosa Maria Affonso Moysés

Abstract

During haemodialysis, calcium balance can affect, or be affected by, mineral metabolism. However, when dialysate calcium concentration (d[Ca]) is chosen or kinetic models are employed to calculate calcium balance, bone remodelling is rarely considered. In this study, we examined whether bone remodelling affects calcium mass transfer during haemodialysis. We dialysed 23 patients using a d[Ca] of 1.0, 1.25, 1.5 or 1.75 mmol/L. Calcium mass transfer was measured and associated with remodelling bone factors. Calcium balance varied widely depending on the d[Ca]. Calcium removal was -578 +/- 389, -468 +/- 563, +46 +/- 400 and +405 +/- 413 mg when a d[Ca] of 1.0, 1.25, 1.5 or 1.75 mmol/L was used, respectively (1.0 and 1.25 vs 1.5 and 1.75 mmol/L, P < 0.001; 1.5 vs 1.75 mmol/L, P < 0.05). Univariate analysis showed that calcium balance correlated with calcium gradient, parathyroid hormone (PTH), osteocalcin and dialysis vintage. Multivariate analysis revealed that calcium balance was dependent on calcium gradient, PTH and osteocalcin. These results suggest that bone remodelling could affect calcium mass transfer during haemodialysis.

Associated Clinical Trials

Sep 7, 2017·Bruno Caldin da SilvaBruno Caldin da Silva

References

Aug 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S H HouJ E Bourdeau
Jul 17, 1986·The New England Journal of Medicine·E SlatopolskyJ Delmez
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M WangY Pei
Jul 1, 1995·Journal of the American Society of Nephrology : JASN·E FernándezJ Montoliu
Feb 1, 1993·Kidney International·D J SherrardG V Segre
Jun 3, 1999·Kidney International·P Ureña, M C De Vernejoul
Mar 4, 2000·Journal of Bone and Mineral Metabolism·T SaisuH Moriya
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christopher R Blagg
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric M Gibney, David S Goldfarb
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonHasan Adda
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin J MartinUNKNOWN Bone Turnover Work Group
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Jan 18, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Mhairi Sigrist, Christopher W McIntyre
Feb 24, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marta AlbalateCarlos Caramelo
Dec 16, 2006·Blood Purification·F GotchN Levin

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Citations

May 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus Pirklbauer, Gert Mayer
Feb 24, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gianmario BosticardoPietro Ravani
Apr 27, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juergen BommerEberhard Ritz
Nov 12, 2010·Seminars in Dialysis·Sharon M Moe
May 24, 2011·International Journal of Nephrology·Carlo Basile
Oct 18, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Carlo BasileCarlo Lomonte
Apr 12, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yukinao SakaiShuichi Tsuruoka
Sep 27, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edward G Clark, Deborah L Zimmerman
May 11, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amit LangoteDeborah Zimmerman
Aug 27, 2013·Journal of Electrocardiology·Dimitrios PoulikakosMarek Malik
Oct 27, 2016·European Journal of Clinical Investigation·Markus PirklbauerGert Mayer
Apr 14, 2017·American Journal of Nephrology·Valeria R C ÁlvaresRosilene M Elias
Apr 20, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Anthony J Bleyer
Feb 7, 2017·Hemodialysis International·Salvatore di FilippoFrancesco Locatelli
Jul 31, 2018·PloS One·Patricia Taschner GoldensteinRosa Maria Affonso Moysés
Aug 24, 2018·International Urology and Nephrology·Melani R CustodioVanda Jorgetti
Oct 28, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Rosilene M EliasRosa M A Moysés
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Leandro Junior LuccaUNKNOWN Sociedade Brasileira de Nefrologia

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