Effects of Bothrops alternatus venom in zebrafish: a histopathological study

Inflammopharmacology
José Carlos Tavares CarvalhoMaria Lúcia Silva

Abstract

Zebrafish is an excellent model organism for studying tissue alterations caused by Bothrops alternatus venom (BAV) and for screening new anti-venom drugs. To study tissue alterations following exposure to BAV and the roles that glucocorticoids play in these tissue reactions, zebrafish were randomly divided into five groups: the free injection control group (FIC), the phosphate-buffered saline injection control group (PIC), the venom injected group (VI), the group treated with dexamethasone 1 h before venom injection (D1hBVI) and the group treated with dexamethasone 1 h after venom injection (D1hAVI). The concentration of BAV injected was 0.13 mg/mL and each fish received an injection of 20 μL. Body weight measurements and histopathological characteristics of the gills, kidneys, liver, and intestine were determined. Histopathological analyses showed necrosis, inflammation and weight gain in animals that received BAV. The histological alteration indices of the gills, liver, kidneys, and intestines were statistically higher in the animal groups treated with BAV. These alteration indices were lower in the D1hBVI and D1hAVI groups compared to the group treated with BAV alone. The D1hBVI group is presented with minor alterations. A s...Continue Reading

References

Mar 29, 2000·Toxicon : Official Journal of the International Society on Toxinology·V L PetricevichJ M Gutiérrez
Dec 18, 2002·Ecotoxicology and Environmental Safety·Mário Pacheco, Maria Ana Santos
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·C J da SilvaL A Ribeiro
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Ana M BarbosaJosé C Cogo
Jul 9, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A Q GuimarãesA Lôbo de Araújo
Dec 20, 2005·Toxicon : Official Journal of the International Society on Toxinology·Marisa M Teixeira RochaMaria de Fátima D Furtado
May 17, 2007·Current Neurovascular Research·Chi-Hsin HsuChiranjib Chakraborty
Mar 5, 2011·Nature Protocols·Priya MathurSu Guo
Aug 19, 2011·Fish Physiology and Biochemistry·Ileana C TroncosoMaría de Los Angeles Bistoni

❮ Previous
Next ❯

Citations

Sep 15, 2020·Inflammopharmacology·Helison de Oliveira CarvalhoJosé Carlos Tavares Carvalho
Aug 11, 2019·Current Topics in Medicinal Chemistry·F A Nogueira JúniorH S Azul Monteiro

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensor

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Elziliam Aranha de SousaJocivânia Oliveira da Silva
South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
L Pantanowitz, B Rabinowitz
© 2022 Meta ULC. All rights reserved