Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial

Plastic and Reconstructive Surgery
Li HuXiaoxi Lin

Abstract

Early intervention might improve the quality of surgical scars. Botulinum toxin type A has been shown to improve surgical scars in the past decade. The purpose of this study was to evaluate the effect of botulinum toxin type A on surgical facial scars. In this prospective, split-scar, double-blind, randomized controlled trial, 16 consecutive patients who underwent facial surgery between June and October of 2015 were enrolled. Botulinum toxin type A was injected randomly into half of each surgical wound closure immediately after surgery. The scars were assessed independently by two plastic surgeons at a 6-month follow-up visit using the Vancouver Scar Scale and the visual analogue scale. The scar width was also measured. Fourteen patients completed the study. The visual analogue scale score and scar width measurements revealed a significant improvement in appearance and narrower scars for the botulinum toxin type A-treated halves of the scars (p = 0.046 and p = 0.001, respectively). The mean Vancouver Scar Scale score was 4.68 for the botulinum toxin type A-injected group and 5.24 for the control group (p = 0.15). In addition, the Vancouver Scar Scale height score was significantly different between the two groups (p = 0.008). T...Continue Reading

References

Jan 16, 1998·Ophthalmic Plastic and Reconstructive Surgery·J C ChoiJ W Shore
Mar 10, 2001·Plastic and Reconstructive Surgery·Wayne F. Larrabee
May 3, 2006·Plastic and Reconstructive Surgery·Adel M Wilson
Aug 12, 2006·Mayo Clinic Proceedings·Holger G GassnerDavid A Sherris
Jun 17, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Xiao Zhibo, Zhang Miaobo
Nov 28, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Samuel Ignacio Pascual-Pascual, Ignacio Pascual-Castroviejo
Nov 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Austin LiuDavid M Ozog
Oct 30, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Makram ZiadeJacques Yachouh
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Bong Kyun AhnHei Sung Kim
Jun 6, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Youn Sung KimHei Sung Kim
Aug 28, 2014·Plastic and Reconstructive Surgery·Chun-Shin ChangPhilip Kuo-Ting Chen
Mar 31, 2015·Clinical and Experimental Dermatology·M LeraM Á Idoate
Feb 13, 2016·Seminars in Neurology·Stephen D Silberstein
Jul 18, 2016·Journal of the Neurological Sciences·John FezzaAmit Verma

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Citations

Mar 1, 2019·Archives of Plastic Surgery·Bushra Alhazmi, Salah Aldekhayel
Mar 1, 2019·The Journal of Craniofacial Surgery·Jason J YooSeth R Thaller
Jun 11, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kevin J ZuoRobert Cartotto
Oct 18, 2019·Lasers in Surgery and Medicine·Arielle N B KauvarPaul M Friedman
Jan 25, 2020·The Journal of Craniofacial Surgery·Sen ChenYangqun Li
Jul 13, 2020·Journal of Cosmetic Dermatology·Patrycja BartkowskaOskar Komisarek
Jun 27, 2020·Plastic and Reconstructive Surgery·Matthew D FreemanPeter J Taub
Dec 15, 2018·Journal of Cosmetic Dermatology·Lorna Martin Kasyanju CarreroBing-Rong Zhou
Jul 9, 2020·Scars, Burns & Healing·Catrin Sohrabi, Ioannis Goutos
Jul 7, 2020·BioMed Research International·Na ZhouYuhong Wang
Jul 12, 2020·American Journal of Clinical Dermatology·Tina S Alster, Iris S Harrison
Oct 8, 2020·Journal of Cosmetic Dermatology·Pengfei SunBo Pan
Feb 1, 2021·Facial Plastic Surgery : FPS·Caroline Hudson, Krista Olson
Apr 14, 2021·Journal of the American Academy of Dermatology·Matthew J LinHooman Khorasani
Jun 24, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yawei LiZhigang Cai
Jun 15, 2021·Seminars in Plastic Surgery·Shayan M SarramiRobert F Dempsey
Oct 27, 2021·The Australasian Journal of Dermatology·Sadrollah MotamedAbdolreza Roeintan
Jul 3, 2021·Scientific Reports·Zhiyou ChenGuangshuai Li
Jul 17, 2021·The Journal of Craniofacial Surgery·Jubin SonaneRaman Sharma

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