Effects of bovine prostate powder on zinc, glucose, and insulin metabolism in old patients with non-insulin-dependent diabetes mellitus

Metabolism: Clinical and Experimental
M K SongK W Kang

Abstract

Since rabbit prostate extract strongly stimulated intestinal zinc absorption and improved the diabetic condition of streptozotocin-induced diabetic rats, we examined the effects of 200 mg bovine prostate powder supplemented with 20 mg zinc (Pro-Z) on the clinical manifestations of older male patients with type II diabetes. Twenty-two male patients who received Pro-Z capsules two to four times per day for 3 months showed reduced mean fasting blood glucose levels from 202 to 169 mg/dL, hemoglobin A1C-(HbA1C) concentrations from 12.2% to 9.5%, and mean values for the 3-hour area response above the fasting glucose concentration (TAFGC) from 141 to 102 mg glucose/dL/h. In eighteen patients who received placebo, mean values for fasting blood glucose decreased from 167 to 165 mg/dL and HbA1C from 10.4% to 10.2%, and for TAFGC increased from 121 to 126 mg glucose/dL/h. No detrimental changes occurred in the liver and kidney function of patients receiving either Pro-Z or placebo. However, blood cholesterol and low-density lipoprotein in patients receiving Pro-Z decreased slightly, whereas values in the placebo group tended to increase. The mean fasting plasma insulin decreased 15.5 to 13.8 microU/mL in subjects given Pro-Z, while the zi...Continue Reading

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Citations

Nov 10, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jasmine CapdorSamir Samman
Nov 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Li-Ching LinChing-Hsiung Chang
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Li-Ching LinFong-Chia Lin
Oct 25, 2016·Neuroscience·Bo Young ChoiSang Won Suh
Mar 4, 2005·Treatments in Endocrinology·Dominique Bonnefont-Rousselot
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Apr 8, 2003·Nutrition·Michael J HaasArshag D Mooradian

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