PMID: 3353874Jan 1, 1988Paper

Effects of breathing supplemental oxygen before progressive exercise in patients with chronic obstructive lung disease

J L McKeonN A Saunders


A study was carried out to determine whether supplemental oxygen before exercise would improve maximum exercise performance and relieve exertional dyspnoea in 20 patients with chronic obstructive lung disease (mean FEV1 0.79 l; forced vital capacity 2.30 l). Patients performed two progressive treadmill exercise tests to a symptom limited maximum, with at least 30 minutes rest between tests. They received compressed air or supplemental oxygen from nasal prongs for 10 minutes before exercise in a double blind randomised trial with a crossover design. Heart rate and breathlessness score on a visual analogue scale were compared between tests at 75% of the maximum distance walked in the compressed air test. The mean arterial oxygen saturation (SaO2) after oxygen (93%) was significantly higher than after compressed air (91%). There was no significant change, however, in maximum distance walked or maximum heart rate, or in the breathlessness score or heart rate at 75% of maximum distance walked. The study had a power of 93% for detecting an increase of 50 metres in maximum distance walked. There was an order effect, with better performance on the second test; but the magnitude of the difference was small. It is concluded that administ...Continue Reading


Jul 9, 1977·British Medical Journal·R J Leggett, D C Flenley
Dec 1, 1986·European Journal of Clinical Investigation·A HenriquezP Sadoul
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·R I Stewart, C A Lewis


Feb 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yu ChenShengqi Li
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Mark B ParshallAmerican Thoracic Society Committee on Dyspnea
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Hope E UronisAmy P Abernethy
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Hope E Uronis, Amy P Abernethy
Dec 14, 2012·Expert Review of Respiratory Medicine·Surinder K Jindal, Ritesh Agarwal
Nov 27, 2009·COPD·Ralph J Panos, William Eschenbacher
Jul 8, 2010·Chest·James K StollerLong-term Oxygen Treatment Trial Research Group
Jun 3, 2011·Archivos de bronconeumología·Karina Dela ColetaIrma Godoy
Feb 13, 2004·Respiratory Medicine·Sara BoothExpert Working Group of the Scientific Committee of the Association of Palliative Medicine
Jun 2, 2006·Respiratory Medicine·Brenda O'NeillJ M Bradley
Nov 11, 2005·Chronic Respiratory Disease·D Górecka
Apr 20, 2007·The Cochrane Database of Systematic Reviews·M L NonoyamaR S Goldstein
Nov 26, 2013·The Cochrane Database of Systematic Reviews·Claudia BauseweinIrene J Higginson
Nov 26, 2016·The Cochrane Database of Systematic Reviews·Magnus EkströmDavid Currow

Related Concepts

Cardiopulmonary Exercise Test
Lung Diseases, Obstructive
Oxygen Therapy Care

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.