Effects of breviscapine on amyloid beta 1-42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Hongjun XiaXiaoqun Ge

Abstract

Herba Erigerontis has long been used to cure apoplexy hemiplegia and precordial pain in China. In addition, the bioactivities of its total flavonoids-breviscapine included inhibiting amyloid beta (Aβ) fibril formation, antioxidation and metal chelating, which are beneficial to treat Alzheimer's disease (AD). Hence, A HPLC-QTOF-MS based plasma metabonomics approach was applied to investigate the neuroprotective effects of breviscapine on intracerebroventricular injection of aggregated Aβ 1-42 induced AD mice for the first time in the study. Ten potential biomarkers were screened out by multivariate statistical analysis, eight of which were further identified as indoleacrylic acid, C16 sphinganine, LPE (22:6), sulfolithocholic acid, LPC (16:0), PA (22:1/0:0), taurodeoxycholic acid, and PC (0:0/18:0). According to their metabolic pathways, it was supposed that breviscapine ameliorated the learning and memory deficits of AD mice predominantly by regulating phospholipids metabolism, elevating serotonin level and lowering cholesterols content in vivo.

Citations

Jan 30, 2018·Frontiers in Neurology·Jordan Maximillian Wilkins, Eugenia Trushina
May 26, 2020·The International Journal of Neuroscience·Xiao-Long LiYuan Xie
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanyan ZhouBaolin Bian
Oct 7, 2021·Critical Reviews in Food Science and Nutrition·Zhijun YangHui-Lian Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Yong HuangMingyan Chi
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Michael C DonohueRobert A Rissman
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
Yuji Goto, Masaru Hoshino
© 2022 Meta ULC. All rights reserved