Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma

Annals of the American Thoracic Society
J ChakirMichel Laviolette

Abstract

The aim of bronchial thermoplasty is to improve asthma symptoms by reducing central airway smooth muscle mass. Up to now, the reduction of smooth muscle mass has been documented for only 1 group of 10 patients who had 15% or more of their pretreatment total bronchial biopsy area occupied by smooth muscle. To evaluate the effects of bronchial thermoplasty on airway smooth muscle mass and airway collagen deposition in adult patients with asthma, regardless of pretreatment smooth muscle area. Seventeen patients with asthma underwent bronchial thermoplasty over the course of three visits. At Visit 1, bronchial biopsies were taken from the lower lobe that was not treated during this session. At Visit 2 (3-14 wk after the first visit), all 17 patients underwent biopsy of the lower lobe treated during the first procedure. At Visit 3 (7-22 wk after the first visit), nine patients agreed to undergo biopsy of the same lower lobe. Histological and immunohistochemical analyses were performed on the biopsy specimens. Bronchial thermoplasty decreased airway smooth muscle from 12.9 ± 1.2% of the total biopsy surface at Visit 1 to 4.6 ± 0.8% at Visit 2 (P < 0.0001). For the nine patients who underwent a third biopsy, mean airway smooth muscle ...Continue Reading

Citations

Apr 14, 2016·Allergo Journal International·Marek Lommatzsch, Paul Stoll
May 28, 2016·The Lancet. Respiratory Medicine·Abhaya TrivediMario Castro
Jul 13, 2016·Immunology and Allergy Clinics of North America·Reynold A Panettieri
Mar 24, 2016·Chest·Balaji LaxmananD Kyle Hogarth
Oct 4, 2016·Trends in Molecular Medicine·Amy Chang, Ynuk Bossé
Oct 26, 2016·The Journal of Allergy and Clinical Immunology·Marina PretolaniMichel Aubier
Jan 20, 2017·Internal Medicine Journal·David LangtonErica Wood
Feb 6, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bradley E ChippsJudith R Farrar
Jun 16, 2018·F1000Research·Ajay P NayakRaymond B Penn
Jun 4, 2021·Journal of Asthma and Allergy·Anne Chetty, Heber C Nielsen
Jun 19, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Satoshi AnoNobuyuki Hizawa

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