Effects of bronchodilation on biomarkers of peripheral airway inflammation in COPD

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Pierachille SantusMarco Contoli

Abstract

Peripheral airway inflammation and dysfunction are key elements in the pathogenesis of COPD. The exhaled alveolar fraction of nitric oxide (CANO) is an indirect biomarker of lung peripheral inflammation. We tested whether inhaled long-acting bronchodilators (LABA) can affect CANO and we evaluated correlations with lung mechanics in patients with COPD. Two-centre, randomised, double blind, crossover study including COPD patients with moderate-to-severe airflow obstruction. Following a pharmacological washout, multi-flow exhaled fraction of NO (FENO), plethysmography, lung diffusion (DLCO), single breath nitrogen washout test and dyspnoea were measured in a crossover manner at baseline and 30, 60 and 180 min following administration of salmeterol (Sal) or formoterol fumarate (FF). (ClinicalTrials.gov, number NCT01853787). Fort-five patients were enrolled (median age: 71.8 years; 84.4% males). At baseline, CANO correlated with airway resistances (r = 0.422), residual volume/total lung capacity (RV/TLC; r = 0.375), transfer factor (r= -0.463) and forced expiratory volume in 1 s (FEV1; r= -0.375, all P < 0.01). After LABA administration, we found a significant reduction of FENO that reached statistical significance at 180'; no diffe...Continue Reading

Citations

Feb 26, 2019·Journal of Breath Research·Silvia Pérez-BogerdAlain Van Muylem
Oct 5, 2019·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Pierachille SantusDejan Radovanovic
Jul 2, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Alberto BraghiroliNicola Scichilone
Jan 13, 2019·Respiratory Research·B BakeA-C Olin
Jun 5, 2020·Current Medicinal Chemistry·Lauri LehtimäkiMarieann Högman

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