Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats

Journal of Ethnopharmacology
Hsien-Tsung YaoTeng-Kuang Yeh

Abstract

Bu-Zhong-Yi-Qi-Tang (BT) is the dry powder derived from the aqueous extract of a mixture of 10 medicinal herbs. It is a traditional Chinese medicine being used for the treatment of various immune-related diseases. To investigate the effect of BT on hepatic drug-metabolizing enzymes and its effect on plasma concentrations of tolbutamide, a substrate of CYP2C, in rats. EXP 1: Thirty-two male Wistar rats were divided into four groups. Rats were fed a control diet and a control diet containing 1, 2.5 and 5% (w/w) of BT, respectively, for eight weeks. The activities of the major CYP and Phase II conjugating enzymes in rat liver microsomes as well as the antioxidant system in rat liver were assessed. Exp 2: Male Wistar rats were fed a control diet or a control diet containing 2.5% of BT, respectively, for eight weeks. A single 20-mg/kg oral dose of tolbutamide was then administered to each rat. Plasma samples were collected from each rat at 0.5, 1, 2, 4 and 8h after dosing. The concentrations of tolbutamide and glucose level in plasma were determined by high-performance liquid chromatography-mass spectrometer (HPLC/MS) and enzymatic method, respectively. Significant decrease in microsomal CYP2C-catalyzed diclofenac 4-hydroxylation in...Continue Reading

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Citations

Oct 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Sophia Yui Kau FongZhong Zuo
May 2, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tongya YuShirui Mao
Jan 5, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shuhei FukunoHiroki Konishi
Jun 9, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Jing LiNa Gao
Jan 8, 2019·Journal of Zhejiang University. Science. B·Bongki ParkMyeong Soo Lee

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