PMID: 42598Oct 1, 1979

Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albumin in vivo and in vitro

Gastroenterologia Japonica
T YamamotoI Kuwahara

Abstract

Bucolome, one of barbiturate derivatives, lowers plasma bilirubin in Gilbert's syndrome without inductive effect on liver microsomal enzymes. To clarify the mechanism of this action, the study was performed concerning the effects of bucolome and five other closely related barbiturate derivatives including phenobarbital (PB) on plasma bilirubin in homozygous Gunn rats and on albumin-bilirubin binding in vitro. When 15 mg/100 g of bucolome was administered to Gunn rats, remarkable drop in plasma bilirubin continued for more than 48 hrs. This decrease of bilirubin was returned to preinjection level after intravenous injection of albumin. Three Gunn rats died as a result of administration of 30 mg/100 g. This dose caused no pathological change in control rats. In in vitro study, bucolome displaced bilirubin from human albumin strongly. PB had almost no effect on the plasma bilirubin in Gunn rats and the in vitro action was very small. Among the barbiturate derivatives, compounds which have cyclohexyl radicals in N position showed stronger plasma bilirubin decreasing effects in Gunn rats. From these results, a strong action to displace bilirubin from plasma albumin is concluded as the mechanism of bucolome to decrease plasma bilirubin.

References

Jul 1, 1977·Archives of Disease in Childhood·G SegniC Romagnoli
Apr 1, 1978·Archives of Disease in Childhood·T Yammoto, Y Adachi
May 1, 1975·The Journal of Pediatrics·G NathensonH McNamara
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·D Bratlid
Feb 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Ichida, M Nobuoka

Related Concepts

Metazoa
Barbiturates
Bilirubin, (4E,15E)-Isomer
Gilbert Disease (Disorder)
Hyperbilirubinemia
Luminal
Plasma Albumin
Sodium Salicylate
Rats, Laboratory
In Vitro [Publication Type]

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