Effects of buffer agents on postresuscitation myocardial dysfunction

Critical Care Medicine
S SunM Fukui

Abstract

Earlier studies demonstrated that hypertonic buffer agents administered during cardiopulmonary resuscitation (CPR) altered neither myocardial pH nor cardiac resuscitability. The rationale for the routine use of buffer agents for CPR has therefore been challenged. However, when these buffer agents are administered during CPR, they may have favorable effects on the postresuscitation course. Postresuscitation myocardial dysfunction has more recently emerged as a potentially fatal complication after successful cardiac resuscitation. Options for prevention and management of this complication have prompted the present studies, in which the effects of buffer agents administered during CPR are evaluated as to their effects on postresuscitation myocardial function and survival. Prospective, randomized, controlled animal study. University animal laboratory. Forty male Sprague-Dawley rats (450 to 570 g). Ventricular fibrillation was induced electrically. Mechanical Ventilation and percordial compression were initiated after either a 4- or an 8-min interval of untreated cardiac arrest. Sodium bicarbonate as a CO2-generating buffer, Carbicarb and tromethamine as CO2-consuming buffers, or hypertonic saline placebo were injected as a bolus in...Continue Reading

References

Jan 1, 1992·The American Journal of Emergency Medicine·T P AufderheideB Thompson
Feb 1, 1990·Journal of the American College of Cardiology·R J GazmuriE C Rackow
Jul 1, 1988·Journal of Clinical Pharmacology·M von PlantaE C Rackow
Jul 17, 1986·The New England Journal of Medicine·M H WeilM I Griffel
Dec 1, 1988·Journal of Applied Physiology·I von PlantaE C Rackow
Sep 1, 1988·The Journal of Clinical Investigation·M KitakazeE Marban
Apr 1, 1970·Annals of Internal Medicine·S J FillmoreT Killip
Jul 1, 1981·American Journal of Clinical Pathology·M H WeilR W Carlson
Apr 1, 1995·Journal of Applied Physiology·B A JohnsonD McCandless
Jul 1, 1993·Critical Care Medicine·W TangJ Bisera
Feb 1, 1993·Anesthesiology·F A MaldonadoA D'Alessio
Jun 1, 1993·Critical Care Medicine·F KetteE C Rackow
Dec 1, 1961·Revista brasileira de anestesiologia·A de ALMEIDA
Feb 22, 1964·British Medical Journal·H GARLAND, D SUMNER
Feb 22, 1964·British Medical Journal·J S STEWART
Jul 9, 1960·JAMA : the Journal of the American Medical Association·W B KOUWENHOVENG G KNICKERBOCKER
Dec 16, 1961·JAMA : the Journal of the American Medical Association·J R JUDEG G KNICKERBOCKER
Apr 1, 1970·California Medicine·W P Longmire, P Henney

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Citations

Jul 1, 1997·Disease-a-month : DM·M H Weil, W Tang
Nov 6, 2001·Journal of the American College of Cardiology·S SunK Klouche
Sep 14, 1999·Journal of the American College of Cardiology·W TangJ Bisera
Jul 20, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·S Hachimi-IdrissiUNKNOWN International Liaison Committee on Resuscitation (ILCOR)
Sep 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M G AngelosC W Callaway
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A Kraut, I Kurtz
Apr 6, 2004·Journal of the American College of Cardiology·Wanchun TangDavid Snyder
Apr 16, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Byung Kook LeeYong Il Min
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·W TangE Mason

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