Effects of buprenorphine sublingual tablet maintenance on opioid drug-seeking behavior by humans

Psychopharmacology
Mark K GreenwaldChris-Ellyn Johanson

Abstract

Buprenorphine can decrease opioid self-administration by humans and animals, but its ability to decrease drug-seeking behavior and craving (i.e. motivational measures) among outpatient volunteers using clinically relevant dosing schedules has not been extensively studied. We investigated whether daily versus alternating-day administration of high versus low buprenorphine doses influenced choice of, and operant responding for, hydromorphone versus money. Fourteen heroin-dependent outpatients were maintained under four buprenorphine sublingual tablet (double blind) dose conditions using a within-subject, randomized crossover design. All participants received, for 2 weeks each, buprenorphine doses of 2 mg daily, 4 mg/placebo on alternating days, 16 mg daily, and 32 mg/placebo on alternating days. In each laboratory test session, participants chose between money ($2/choice) and drug (1/8 of total hydromorphone, 4 or 24 mg IM in different sessions) alternatives using an eight-trial non-independent progressive ratio schedule (FR 100, 200,.12,800). The drug dose and money amount earned was delivered after the end of the 2.5-h work period. Hydromorphone 24 mg was more reinforcing than 4 mg. Higher versus lower average buprenorphine dos...Continue Reading

Citations

Dec 24, 2002·Human Psychopharmacology
May 10, 2003·Drug and Alcohol Dependence·Sharon L Walsh, Thomas Eissenberg
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark K GreenwaldCaren L Steinmiller
Mar 31, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E SorgeJane Stewart
Feb 24, 2012·Journal of Addictive Diseases·Ayman FareedKaren Drexler
Jul 3, 2013·Journal of Addictive Diseases·Ayman FareedKaren Drexler
Jul 11, 2013·Behavioural Pharmacology·Jermaine D Jones, Sandra D Comer
Apr 26, 2008·Drug and Alcohol Dependence·S D ComerS L Walsh
Feb 6, 2008·Journal of Substance Abuse Treatment·Hendree E JonesGabriele Fischer
Dec 17, 2011·Annals of the New York Academy of Sciences·Stephen T Tiffany, Jennifer M Wray
Dec 20, 2011·The American Journal of Drug and Alcohol Abuse·Ayman FareedKaren Drexler
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Dec 1, 2017·Expert Opinion on Pharmacotherapy·Maurice DematteisMichael Soyka
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark K GreenwaldJon-Kar Zubieta
Oct 20, 2010·The American Journal of Drug and Alcohol Abuse·Ayman FareedKaren Drexler
May 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Stacy L SellCharles P France
Oct 18, 2003·The Journal of Pharmacology and Experimental Therapeutics·Maciej GasiorJack Bergman
Jan 10, 2020·Drug Development and Industrial Pharmacy·Peter HjelmströmFredrik Tiberg
Aug 20, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V D Mendelevich
Jan 15, 2020·Cold Spring Harbor Perspectives in Medicine·E Andrew TownsendMatthew L Banks
Dec 4, 2020·Drug and Alcohol Dependence·E Andrew TownsendMatthew L Banks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.