PMID: 9244363Jan 1, 1997

Effects of buspirone on dopaminergic supersensitivity

Life Sciences
C M Queiroz, R Frussa-Filho


The effects of buspirone treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both spontaneous activity (locomotion and rearing frequencies) of rats observed in an open-field and apomorphine-induced stereotypy were used as experimental parameters. Buspirone per se (3.0 mg/kg, twice daily, for 30 days) did not produce dopaminergic supersensitivity. When buspirone was given in combination to haloperidol (2.0 mg/kg, once daily, for 30 days), it decreased the neuroleptic withdrawal symptoms as detected in open-field behavior but not in apomorphine-induced stereotypy. Although single administration of buspirone per se decreased both open-field and apomorphine-induced stereotypy behavior, buspirone single administration did not modify the acute effects of haloperidol on these two behavioral models. Taken together with previous behavioral results showing that buspirone reverses haloperidol-induced catalepsy, the present data suggest that buspirone co-administration may lead to important clinical advantages concerning different extrapyramidal side effects of neuroleptic treatment.


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Jun 17, 2000·European Journal of Pharmacology·T A ReaderR Lalonde
Apr 23, 2003·Life Sciences·V C AbílioR Frussa-Filho
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·R CareyG De Palma
Jan 13, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·C M Queiroz, R Frussa-Filho
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Dec 16, 2010·The International Journal of Neuropsychopharmacology·Daniela F Fukushiro, R Frussa-Filho
Feb 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M T QueirozR Frussa-Filho
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