PMID: 9528687Apr 7, 1998Paper

Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats

Chemico-biological Interactions
R MundayC M Munday

Abstract

The enzyme DT-diaphorase catalyses the 2-electron reduction of quinones. This reaction may facilitate the detoxification of such compounds, since the hydroquinone so formed can be converted into non-toxic conjugates. There is evidence for the involvement of DT-diaphorase in the detoxification of menadione (2-methyl-1,4-naphthoquinone) in a wide range of cells and tissues in vitro, but no information is available on the possible influence of this enzyme on the harmful effects of menadione in vivo. In animals, menadione is selectively toxic to erythrocytes, causing haemolytic anaemia. In the present study, rats were treated with dicoumarol, an inhibitor of DT-diaphorase, or butylated hydroxyanisole (BHA), a substance that increases the activity of this enzyme in vivo. They were then challenged with a toxic dose of menadione. Dicoumarol increased the severity of menadione-induced haemolytic anaemia while BHA decreased it, consistent with a role for DT-diaphorase in the detoxification of menadione in vivo, as previously described in vitro.

References

Aug 1, 1975·Archives of Biochemistry and Biophysics·P M Hollander, L Ernster
Jul 21, 1976·Biochimica Et Biophysica Acta·B Goldberg, A Stern
Jan 1, 1991·Chemico-biological Interactions·P J O'Brien
Jun 15, 1988·Biochemical Pharmacology·A S AtallahP Hochstein
Jan 1, 1989·Journal of Inherited Metabolic Disease·F A WijburgR B Schutgens
Jan 1, 1987·Pharmacology & Therapeutics·G Powis
Mar 1, 1987·Archives of Environmental Contamination and Toxicology·A A Andaya, R T Di Giulio
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·J Butler, B M Hoey
Mar 1, 1985·Cancer Treatment Reviews·R T ChlebowskiJ B Block
Jan 1, 1967·Biochemistry·R LositoE V Flock
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P L ChesisB N Ames
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S EleffB Chance
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M BensonP Talalay
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·K A MargolinJ H Doroshow
May 1, 1993·Chemical Research in Toxicology·L Flowers-GearyT M Penning
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M TetefS Shibata
Jul 1, 1994·Journal of Molecular and Cellular Cardiology·W F TzengY H Chen
Jan 1, 1995·Investigational New Drugs·M TetefJ H Doroshow
May 1, 1959·The Journal of Pediatrics·C GASSER
Apr 9, 1962·Biochimica Et Biophysica Acta·L ERNSTERM LJUNGGREN
Sep 1, 1963·The Journal of Nutrition·A M PAOLUCCIB C JOHNSON
Dec 1, 1945·Journal of Dental Research·E H HATTON, A DOODS
Jun 1, 1997·Redox Report : Communications in Free Radical Research·R Munday

❮ Previous
Next ❯

Citations

Dec 30, 1999·Toxicology·T J ChiouW F Tzeng
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Sep 5, 2008·Neurochemical Research·Ikuko Miyazaki, Masato Asanuma
Nov 24, 2004·Drug Metabolism Reviews·David Ross
Sep 22, 2009·European Journal of Pharmacology·Syed M QadriFlorian Lang
Nov 24, 2004·Biochemical and Biophysical Research Communications·Jessica MontoyaRenato J Aguilera
Apr 6, 1999·Chemico-biological Interactions·R MundayC M Munday
Oct 3, 2006·Expert Review of Neurotherapeutics·Masato Asanuma, Ikuko Miyazaki
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ikuko MiyazakiNorio Ogawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.