Effects of Ca2+ entry blockers on CaCl2-, KCl- and noradrenaline-induced contractions of goat cerebral arteries

European Journal of Pharmacology
J B SalomE Alborch

Abstract

The effects of three Ca2+ entry blockers, nicardipine, nimodipine and verapamil, on CaCl2-, KCl- and noradrenaline-induced contractions were examined in isolated goat middle cerebral artery. The relationship between the effects of Ca2+ entry blockers and the extracellular Ca2+ dependence of the contractions was also examined. In 'nominally' Ca2(+)-free medium, addition of CaCl2 induced concentration-dependent contractions of previously depolarized arteries. Withdrawal of Ca2+ from the extracellular medium caused strong inhibition of the KCl- and noradrenaline-induced arterial contractions. Addition of EGTA to the Ca2(+)-free medium almost abolished the noradrenaline-response but did not increase the inhibition of the KCl-induced contractions. The Ca2+ entry blockers induced concentration-dependent relaxation of the precontracted arteries (100 mM KC1) with the following order of potency: nimodipine greater than nicardipine greater than verapamil. The CaCl2-, KCl- and noradrenaline-induced contractions were depressed in a concentration-related manner by nicardipine, nimodipine and verapamil. Dihydropyridines showed a greater inhibitory effect than verapamil. These results show that Ca2+ entry blockers are able to inhibit the cont...Continue Reading

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Citations

Jan 3, 1991·European Journal of Pharmacology·J B SalomE Alborch
Jan 1, 1995·Pharmacology & Therapeutics·E AlborchG Torregrosa
Sep 1, 1996·Drug and Alcohol Dependence·J B SalomE Alborch
Dec 1, 1993·Clinical and Experimental Pharmacology & Physiology·R M Wadsworth
Aug 1, 1997·British Journal of Obstetrics and Gynaecology·A J PeralesE Alborch
Jan 1, 1994·Pharmacology & Therapeutics·P I Aaronson
Aug 1, 2002·Acta Neuropsychiatrica·Brian E Leonard
Nov 19, 2019·Frontiers in Neurology·Corinne FischerWerner J Z'Graggen
Aug 10, 2020·Ultrasound in Medicine & Biology·Silvijus AbramavičiusEdgaras Stankevičius

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