PMID: 9428478Jan 15, 1998Paper

Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover

Cancer
F DworzakF Bozzetti

Abstract

Data available in the literature regarding whole body protein (WBP) kinetics in patients with cachexia due to cancer are conflicting. Some authors have reported an increase of WBP synthesis and breakdown, whereas others have not found any significant changes; only a few researchers have investigated more compartments simultaneously. The main purpose of this study was to investigate WBP and skeletal muscle protein (SMP) turnover simultaneously in cachectic patients to understand better the mechanisms underlying the general wasting of the host present in cancer cachexia. WBP and SMP synthesis and breakdown were studied in malnourished patients with advanced gastric carcinoma and in healthy volunteers. Protein turnover was evaluated in a postabsorptive state, using a model based on a primed constant infusion of L-[(2)H5] phenylalanine and L-[(2)H4]tyrosine, and by determining the isotopic enrichment and concentration in plasma during a plateau phase by gas chromatography and mass spectrometry. Rates of WBP synthesis and breakdown did not differ significantly between the two groups (whole body synthesis [WBS] of 4.35 +/- 0.2 g/kg/day and whole body breakdown [WBB] of 4.77 +/- 0.2 g/kg/day in the control group and WBS of 3.34 +/- 0....Continue Reading

Citations

Oct 7, 2011·Indian Journal of Palliative Care·El Mehdi Tazi, Hassan Errihani
Mar 11, 2008·La Presse médicale·Michel PavicPhilippe Debourdeau
Oct 30, 2003·Cancer·Roberto StasiSergio Amadori

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