PMID: 9179928May 1, 1997Paper

Effects of cadmium on trophoblast calcium transport

Placenta
F J LinR S Tuan

Abstract

Maternal exposure to cadmium (Cd) during pregnancy has been linked to low fetal birthweight, which may be attributed to placental damage and/or dysfunction in nutrient transport. Previous studies have suggested that Cd is accumulated in the placenta, and that placental transport of calcium (Ca) and zinc (Zn) is perturbed by Cd. To investigate the mechanism of Cd perturbation of Ca transport, we used JEG-3, a human choriocarcinoma cell line which exhibits trophoblastic properties, to analyse Cd effects in vitro. Treatment with Cd at low, physiologically relevant concentrations (e.g. 0.04 microM) did not result in obvious changes in cell morphology or integrity, whereas higher concentrations (> or = 0.16 microM) affected cell integrity. With lower concentrations of Cd treatment for 24 h, activities of cellular Ca uptake and transport, and Ca2+ binding were decreased, and intracellular [Ca2+] ([Ca2+]i) profile was also altered; however, membrane-associated Ca(2+)-activated ATPase activity remained relatively unchanged. Interestingly, cellular Ca uptake activity was unaffected by short-term (30 min) Cd pretreatment. The 24-h Cd treatment also resulted in elevated expression of the metal-binding protein, metallothionein, whereas the...Continue Reading

References

May 1, 1977·The Journal of Nutrition·P Washko, R J Cousins
Nov 1, 1976·Pediatric Clinics of North America·R C TsangJ J Steichen
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y KojimaJ H Kägi
Mar 16, 1992·Biochemical and Biophysical Research Communications·A HowardJ R Walters
Oct 11, 1992·Biochemical Medicine and Metabolic Biology·J K HartsfieldD R Hilbelink
Jun 1, 1992·Canadian Journal of Physiology and Pharmacology·M G Brunette, M Leclerc
Feb 14, 1992·Biochemical and Biophysical Research Communications·Y EmotoH Hidaka
Mar 1, 1992·The American Journal of Physiology·S G KamathC H Smith
Jun 15, 1991·Toxicology and Applied Pharmacology·J L Flanagan, P A Friedman
Sep 1, 1991·Toxicology and Applied Pharmacology·M E Blazka, Z A Shaikh
Jun 15, 1991·Toxicology and Applied Pharmacology·J LiuC D Klassen
Jan 1, 1990·The Journal of Physiology·J StulcJ Svihovec
Aug 1, 1990·Toxicology and Applied Pharmacology·P J WierP A DiSant'Agnese
Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·R W TsienR L Rosenberg
Jan 1, 1988·Differentiation; Research in Biological Diversity·R S Tuan, J J Kirwin
Aug 1, 1989·The American Journal of Physiology·J L BorkeR Kumar
Nov 10, 1988·Nature·H Reuter, H Porzig
Jan 1, 1987·The American Journal of Physiology·G J FisherC H Smith
Oct 1, 1988·Canadian Journal of Physiology and Pharmacology·M G Brunette
Oct 5, 1987·Biochimica Et Biophysica Acta·D B Shennan, C A Boyd
May 1, 1988·The Journal of Membrane Biology·P M VerbostS E Wendelaar Bonga
Jan 1, 1986·Annual Review of Biochemistry·D H Hamer
Aug 1, 1986·Journal of Clinical Pathology·C F MonizC H Rodeck
Feb 1, 1985·Molecular and Cellular Biology·M K Yagle, R D Palmiter
Dec 1, 1974·Analytical Biochemistry·D J Stewart
Jan 1, 1972·Annual Review of Biochemistry·B L Vallee, D D Ulmer
Jan 1, 1974·Upsala Journal of Medical Sciences·J Friberg, O Nilsson
May 1, 1971·The Journal of Clinical Endocrinology and Metabolism·P O Kohler, W E Bridson
Sep 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Itaya, M Ui
Feb 15, 1967·Experientia·J Parízek, I Ostádalová

❮ Previous
Next ❯

Citations

Jun 22, 2012·Wiener medizinische Wochenschrift·Claudia Gundacker, Markus Hengstschläger
Dec 12, 2001·Reproductive Toxicology·M PiasekJ W Laskey
Sep 11, 2002·Reproductive Toxicology·Giovanni LeoniSalvatore Naitana
Jun 23, 1999·Reproductive Toxicology·L S JoliboisM B Anderson
Feb 1, 2010·Journal of Developmental Origins of Health and Disease·N C HarveyUNKNOWN SWS Study Team
Jun 1, 2002·Occupational and Environmental Medicine·M NishijoK Tawara
Apr 9, 2008·Pediatric Research·Jacques BeltrandClaire Lévy-Marchal
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K GodfreyC Cooper
Jun 29, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Emmy Van KerkhoveQuirine Swennen
Nov 24, 2007·The Journal of Pediatrics·N Marta Díaz-GómezManuel Moya
Jan 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Mary Frances McAleer, Rocky S Tuan
Jun 1, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Elizabeth Cho, Wan-Ju Li
Oct 31, 2008·Journal of Biochemical and Molecular Toxicology·Laxmipriya P Nampoothiri, Sarita Gupta
Jan 13, 2015·Journal of Environmental and Public Health·Anders C Erickson, Laura Arbour
Apr 30, 2002·Placenta·Keith M Godfrey
May 6, 2015·Journal of Developmental Origins of Health and Disease·G NtaniUNKNOWN Southampton Women’s Survey Study Group
Jul 25, 2006·International Review of Cytology·Julie Lafond, Lucie Simoneau
Sep 26, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Taimei ZhouXiaolong Wei
Oct 17, 2016·Environmental Science and Pollution Research International·Laorrat PhuapittayalertNatthiya Sakulsak
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Natacha Bouhours-NouetGilles Simard
Sep 8, 2005·American Journal of Physiology. Endocrinology and Metabolism·Kaiping YangHaiyan Guan
Mar 25, 2006·Molecular Human Reproduction·S R HanssonM J Brownstein
Jul 25, 2013·American Journal of Physiology. Endocrinology and Metabolism·Johanna SelvaratnamKaiping Yang
Jan 31, 2020·BMJ : British Medical Journal·Judith S BrandScott Montgomery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.