Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status.

Neuroscience Bulletin
H KaloniaB Nehru

Abstract

The neuroprotective roles of cyclooxygenase (COX) and lipooxygenase (LOX) inhibitors have been well documented. Quinolinic acid (QA) is a well-known excitotoxic agent that could induce behavioral, morphological and biochemical alterations similar with symptoms of Huntington's disease (HD), by stimulating NMDA receptors. However, the exact roles of COX and LOX inhibitors in HD have not yet been explained. The present study aims to elucidate the effects of caffeic acid (a specific inhibitor for LOX), rofecoxib (a specific inhibitor for COX-2), and their combination in ameliorating QA-induced neurotoxicity in rats. QA was injected into the right striatum of rats to induce neurotoxicity. Caffeic acid and rofecoxib were then orally administered separately. In the combination study, caffeic acid and rofecoxib were administered together. After that, a series of behavioral assessments were conducted to determine the effects of caffeic acid and rofecoxib, respectively, and the co-effect of caffeic acid and rofecoxib, against QA-induced neurotoxicity. Intrastriatal QA administration (300 nmol) not only induced a significant reduction in body weight and motor incoordination, but also altered the redox status (decreased glutathione and inc...Continue Reading

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Citations

Aug 11, 2012·Pharmacology, Biochemistry, and Behavior·Anil KumarJitendriya Mishra
Oct 4, 2013·Oxidative Medicine and Cellular Longevity·Rafael Lugo-HuitrónVerónica Pérez-de la Cruz
Feb 16, 2015·Plant Foods for Human Nutrition·Felipe Jiménez-AspeeGuillermo Schmeda-Hirschmann
Jul 11, 2012·Mediators of Inflammation·Isabel Vieira de Assis LimaAntonio Carlos Pinheiro de Oliveira
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Jan 1, 2014·Molecular and Cellular Biochemistry·J ChakrabortyK P Mohanakumar
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź

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