Abstract
Calcineurin inhibitors (CIs) such as cyclosporine A (CSA) and tacrolimus often cause renal dysfunction, resulting in increased serum creatinine, hyperkalemia, and hyperuricemia. However, the effects of CIs on sodium excretion have not been fully elucidated. We retrospectively evaluated the effects of CI administration on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). Fifty consecutive recipients each of allogeneic HSCT receiving either CSA or tacrolimus (100 patients in total) with available data for weekly fractional excretion of sodium (FENa) for a 4-week period after transplantation were enrolled in this retrospective analysis. No significant differences in patient characteristics were observed between CSA and tacrolimus groups except for the type of donor. FENa was significantly higher at the 3rd (1.25 ± 0.80) and 4th weeks (1.53 ± 1.06) after transplantation as compared with that at the 1st week (0.93 ± 0.51; P < 0.01, P < 0.001, respectively) in the tacrolimus group, but not at any time point in the CSA group. In addition, FENa was significantly higher in the tacrolimus group than the CSA group at the 4th week (1.53 ± 1.06 vs. 1.13 ± 0.80; P < 0.05). These results suggest that...Continue Reading
References
Jun 1, 1990·The British Journal of Dermatology·J Mason
Jul 1, 1983·American Journal of Nephrology·J UribarriH J Carroll
Feb 18, 1998·Bone Marrow Transplantation·M WooM Körbling
Sep 11, 2001·Experimental Nephrology·S AkerR K Kinne
Jan 24, 2002·Current Opinion in Critical Care·A J OlyaeiW M Bennett
Mar 13, 2002·Lancet·Raimund Margreiter, UNKNOWN European Tacrolimus vs Ciclosporin Microemulsion Renal Transplantation Study Group
Apr 17, 2002·Endocrinology·Christine E DeppeMarc Lombès
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Robert HigginsHabib Kashi
Nov 10, 2005·Transplantation·Yoshinobu AisaShinichiro Okamoto
Apr 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Soumita BagchiRajendra Prasad Mathur
Jun 10, 2011·American Journal of Physiology. Renal Physiology·Kristien J LedeganckBenedicte Y De Winter
Dec 5, 2012·Bone Marrow Transplantation·Y Kanda
Feb 27, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Goce SpasovskiUNKNOWN Hyponatraemia Guideline Development Group
Apr 13, 2015·International Journal of Hematology·Makoto Murata
Jan 24, 2016·International Journal of Hematology·Rika SakaiMakoto Murata
Oct 1, 2016·International Journal of Hematology·Toshihiro MiyamotoKoichi Akashi
Citations
Mar 22, 2019·PloS One·Elizabeth A de KortWalter J F M van der Velden
Oct 10, 2019·Expert Opinion on Drug Metabolism & Toxicology·Yuan Gao, Jingjing Ma
Dec 5, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Iman KarimzadehMani Ramzi