Effects of calcitonin gene-related peptide on canine cerebral artery strips and the in-vivo vertebral blood flow in dogs.

Naunyn-Schmiedeberg's Archives of Pharmacology
I IkegakiK Sugita

Abstract

The effects of calcitonin gene-related peptide (CGRP) on canine cerebral arteries and on vertebral blood flow were investigated in-vivo and in-vitro and the findings compared with the effects of vasoactive intestinal peptide (VIP) and substance P. Administration of CGRP into the vertebral artery caused a dose-dependent and long-lasting increase in blood flow. The in-vivo vasodilatory effects of substance P and VIP were short-lasting. CGRP (0.1 to 100 nmol/l) elicited a concentration-dependent relaxation of the isolated middle cerebral and basilar arteries when the tissues were precontracted by exposure to prostaglandin F2 alpha (PGF2 alpha). This effect was not antagonized by propranolol, atropine, tetrodotoxin, (N-Ac-Tyr1, D-Phe2)-growth hormone-releasing factor(1-29)-NH2 or (D-Pro2, D-Trp7,9) substance P. CGRP also reduced concentration-dependently the contraction of cerebral arteries induced by KCl or 9,11-epithio-11,12-metano-thromboxane A2 (STXA2). Mechanical removal of the endothelium did not abolish the vasodilatory response to CGRP. In PGF2 alpha-contracted canine cerebral arteries, VIP (0.1 to 100 nmol/l) was less potent a vasodilator than CGRP. At low concentrations (0.01 to 1 nmol/l) substance P elicited a rapid and ...Continue Reading

References

Oct 13, 1987·European Journal of Pharmacology·A Franco-CerecedaJ M Lundberg
Oct 15, 1985·Biochemical and Biophysical Research Communications·M KubotaT J Martin
Feb 9, 1988·European Journal of Pharmacology·Y SuzukiT Asano
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Mar 1, 1987·Circulation Research·A Franco-CerecedaJ A Fischer
Aug 1, 1984·Annals of Neurology·M A Moskowitz

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Citations

Oct 16, 1995·European Journal of Pharmacology·M AnzaiM Shibuya
Oct 1, 1994·Immunology Letters·M IsaguliantsB Wahren
Sep 1, 1992·Journal of Neurosurgery·Y SuzukiK Sugita
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OyamaK Sugita
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·Y SuzukiM Shibuya

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