Effects of Calcitonin Gene-Related Peptide on Colonic Motility and Defecation in Conscious Dogs

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Tomoyuki OnoMichiaki Unno

Abstract

Although intra-arterial infusion of calcitonin gene-related peptide (CGRP) reportedly stimulates giant migrating contractions (GMCs) of the small intestine in conscious dogs, the effect of intravenous CGRP administration on colonic motility remains unclear. In the present study, we investigated the effects of intravenous CGRP on colonic motility and defecation and determined the underlying mechanism of action in conscious dogs. Sixteen Beagle dogs weighing 11-13 kg were included. The effects of intravenous CGRP at doses of 3.33 (with various antagonists), 0.83, and 1.67 μg/kg on colonic motility and defecation were evaluated in neurally intact dogs (n = 6). For comparison, dogs with transection/re-anastomosis (T/R) between the proximal and middle segments of the colon (n = 5) and dogs with extrinsic denervation of the ileocolonic segments (n = 5) also received intravenous CGRP at 3.33 μg/kg. All dogs were equipped with strain gauge force transducers on the ileocolon for measurement of the colonic contractile activity. Intravenous CGRP evoked GMCs and defecation in the neurally intact group; these stimulatory effects were inhibited by atropine and hexamethonium. Compared with the neurally intact group, the T/R group exhibited si...Continue Reading

References

Dec 1, 1990·The American Journal of Physiology·R M McAllister, R L Terjung
Apr 30, 1997·Regulatory Peptides·C A MaggiP Santicioli
Jul 11, 2002·Life Sciences·Yukinori NagakuraTokio Yamaguchi
Dec 31, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sushil K Sarna
Apr 12, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S LeelakusolvongS F Phillips
Apr 13, 2007·Digestive Diseases and Sciences·Munenori NagaoIwao Sasaki
Oct 24, 2013·World Journal of Gastroenterology : WJG·Hiroki MoritaHiroyuki Kuwano
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Apr 10, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Soutoku SomeyaMichiaki Unno
May 2, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T R GlowkaS Wehner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

© 2021 Meta ULC. All rights reserved