Effects of calcium alginate on cellular wound healing processes modeled in vitro

Journal of Biomedical Materials Research
J W DoyleR M Dunn

Abstract

Although the clinical experience with calcium alginate has been generally good, well-controlled studies examining the effect of such dressings on the processes of wound healing have not been conducted. The healing of cutaneous ulcers requires the development of a vascularized granular tissue bed, filling of large tissue defects by dermal regeneration, and the restoration of a continuous epidermal keratinocyte layer. These processes were modeled in vitro in the present study, utilizing human dermal fibroblast, microvascular endothelial cell (HMEC), and keratinocyte cultures to examine the effect of calcium alginate on the proliferation and motility of these cultures, and the formation of capillarylike structures by HMEC. This study demonstrates that the calcium alginate tested increased the proliferation of fibroblasts but decreased the proliferation of HMEC and keratinocytes. In contrast, the calcium alginate decreased fibroblast motility but had no effect on keratinocyte motility. There was no significant effect of calcium alginate on the formation of capillarylike structures by HMEC. The effects of calcium alginate on cell proliferation and migration may have been mediated by released calcium ions. These results suggest that ...Continue Reading

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Citations

Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M GuarreraA Rebora
Oct 31, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan B G Lansdown
May 25, 2002·Journal of the American Geriatrics Society·Joël BelminUNKNOWN Investigators of the Sequential Treatment of the Elderly with Pressure Sores (STEPS) Trial
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Apr 13, 2004·Journal of the American Veterinary Medical Association·Ellis G FarstvedtSharon J Spier
Jul 2, 2003·Journal of Clinical Periodontology·Rodrigo F NeivaHom-Lay Wang
Mar 5, 2009·Biomedical Materials·Ikuko Machida-SanoHideo Namiki
Sep 24, 2010·International Wound Journal·Supaporn OpasanonNantaporn Namviriyachote
May 25, 2012·Journal of Biomedical Materials Research. Part a·Jørgen StenvikTerje Espevik
Jun 1, 2018·BioMed Research International·Shinichiro MoritaAkeo Hagiwara
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Cho Hay MunSang-Hoon Lee
Mar 22, 2020·Marine Drugs·Ana DobrinčićVerica Dragović-Uzelac
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·J L ShamshinaR D Rogers
Apr 27, 2012·International Wound Journal·Shi-Bo ZouWoo-Kyung Kim
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Jul 8, 2008·Journal of Drug Targeting·Zelihagül Değim
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Jun 27, 2006·Plastic and Reconstructive Surgery·Joanne E Paddle-LedinekHeather J Cleland
Jun 17, 2015·BioMed Research International·Mari MatobaAkeo Hagiwara
Nov 20, 2019·International Journal of Pharmaceutics·Prabhjot KaurSanjay Chhibber
Jan 29, 2008·Journal of the American Academy of Dermatology·Margaret A FonderAdam J Mamelak

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