Effects of calcium and potassium supplements on arterial tone in vitro in spontaneously hypertensive rats

British Journal of Pharmacology
J P TolvanenI Pörsti

Abstract

1. Calcium and potassium intakes inversely correlate with blood pressure in experimental hypertension. Therefore, we examined the effects of calcium and potassium supplements alone and in combination on arterial tone in spontaneously hypertensive rats (SHR). Wistar-Kyoto (WKY) rats served as normotensive controls. Calcium and potassium contents in the control diet were both 1%, while those in supplemented chows were 3% and 3.5%, respectively. The sodium content of all diets was moderately elevated to 1.1%. 2. After 12 weeks of the study systolic blood pressures in SHR on high calcium and on high potassium diets were markedly lower (about 53 and 58 mmHg, respectively) than in hypertensive controls, while combined supplementation of these cations reduced blood pressure even further (about 69 mmHg). 3. Responses of mesenteric arterial rings in vitro were examined at the end of the study. Both high calcium and high potassium diets improved the impaired relaxation to acetylcholine (ACh) in SHR, while the combination of these supplements completely normalized this response. Cyclo-oxygenase inhibition by diclofenac augmented the relaxation to ACh in hypertensive controls but not in the other groups. Nevertheless, enhanced endothelium-...Continue Reading

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Citations

Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michel Félétou, Paul M Vanhoutte
Sep 25, 2003·The Journal of Nutritional Biochemistry·Timo Vaskonen
Jun 5, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Raymond I OzoluaSamuel O Asagba
Jul 9, 2011·The British Journal of Nutrition·Pauliina I EhlersHeikki Vapaatalo
Mar 31, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·John M FlackPhillip D Levy
Jan 31, 2012·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Lu WangHoward D Sesso
Aug 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Selahattin KumruZeynep Ozcan
Sep 20, 2000·Journal of Hypertension·J Hilary GreenR L Bunning
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P JolmaI Pörsti
Oct 12, 1999·The American Journal of Physiology·J KalliovalkamaI Pörsti
Feb 2, 2002·The Journal of Nutrition·Timo VaskonenHeikki Karppanen

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