Effects of calcium and strontium in the process of acetylcholine release from motor nerve endings

The Journal of Physiology
A M MellowE M Silinsky

Abstract

1. The effects of Ca and Sr ions on synchronous acetyleholine (ACh) secretion (the impulsive, physiologically functional form of secretion which produces an end-plate potential in response to a single nerve impulse) and on asynchronous ACh secretion (the delayed, residual increase in miniature end-plate potential frequency evoked by repetitive nerve impulses or by accumulation of intracellular divalent cations) were studied at frog neuromuscular junctions.2. In a comparison of their extracellular effects, Ca was far more effective than Sr in supporting synchronous ACh secretion but less effective than Sr in mediating asynchronous release evoked by repetitive nerve impulses.3. In studies of their intracellular effects, Sr and Ca were delivered to the nerve terminal cytoplasm using liposomes as a vehicle. Ca-containing liposomes, although producing effects on asynchronous ACh secretion that were indistinguishable from those of equimolar Sr-containing liposomes, were more effective than Sr-containing liposomes in increasing synchronous release.4. Extracellular Ca behaved as a potent competitve inhibitor of asynchronous, neurally evoked release mediated by Sr. In contrast, intracellular Ca (i.e. liposomal Ca), whilst increasing syn...Continue Reading

Citations

Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ofer WiserDaphne Atlas
Apr 8, 2009·Molecular and Cellular Neurosciences·William L Coleman, Maria Bykhovskaia
Jan 11, 2007·Journal of Neurochemistry·Ellya A BukharaevaLev G Magazanik
Aug 1, 1987·Toxicology and Applied Pharmacology·D L Traxinger, W D Atchison
Jul 1, 1984·Experimental Eye Research·B R Grubb, P J Bentley
Mar 30, 1999·Biophysical Journal·M A Xu-Friedman, W G Regehr
Sep 22, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G S Hahn

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