Effects of calcium channel blockers on the response to endothelin-1, bradykinin and sodium nitroprusside in porcine ciliary arteries

Experimental Eye Research
P MeyerT Lüscher

Abstract

Calcium channel blockers are increasingly used in ophthalmology, for instance in patients with visual field defects caused by vasospasm. Endothelin is a new vasoactive peptide which also has been implicated in hypoperfusion of the ophthalmic circulation. This study investigated the effects of the calcium channel blockers on the response to endothelin-1, bradykinin and sodium nitroprusside in isolated porcine ciliary arteries (diameter 200-250 microns). Isolated porcine ciliary arteries were suspended in myograph systems filled with modified Krebs-Ringer solution (37 degrees C; 95% O2/5% CO2) for isometric tension recording. Endothelin-1 (10(-12) -10(-7) M) induced potent concentration-dependent contractions of porcine ciliary arteries (PD50 = 8.3 +/- 0.1; n = 7). Lacidipine (10(-5) -10(-7) M) and nifedipine (10(-5) M) significantly reduced the contractions and decreased the sensitivity to endothelin-1 as compared to control (P < 0.03). On the other hand, endothelium-dependent relaxations to bradykinin (10(-10) -10(-6) M) and endothelium-independent relaxations to sodium nitroprusside (10(-10) -10(-4) M) remained unaffected by the calcium channel blocker. These findings demonstrate that in porcine ciliary arteries, the calcium c...Continue Reading

References

Jun 1, 1992·Trends in Pharmacological Sciences·W A Catterall, J Striessnig
Feb 1, 1991·Circulation·T F Lüscher
Nov 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·S S Sørensen
Jan 1, 1989·Journal of Cardiovascular Pharmacology·H KuriharaT Masaki
Jan 1, 1989·Annual Review of Physiology·B P Bean
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Y KitazawaF J Go
May 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·P Gasser, J Flammer
Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U GuthauserF Mahler
Aug 1, 1995·Journal of Cardiovascular Pharmacology·C F KüngT F Lüscher
May 1, 1994·Survey of Ophthalmology·G RavalicoM Crocé
Mar 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·G ManciaS Trazzi

❮ Previous
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Citations

Jan 1, 1995·International Ophthalmology·H J KaiserJ Flammer
Feb 11, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E S DettmannI O Haefliger
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie
Jul 23, 1999·Survey of Ophthalmology·S OrgülJ Flammer
Feb 15, 2001·Progress in Retinal and Eye Research·I O HaefligerT F Lüscher
Apr 5, 2001·Progress in Retinal and Eye Research·J FlammerT Resink
Feb 27, 2003·Progress in Retinal and Eye Research·Dao-Yi YuPaula K Yu
Oct 25, 2003·Progress in Retinal and Eye Research·Vital P CostaLuis Metzner Serra
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·N ToriuH Hara
Jul 23, 1999·Annals of the New York Academy of Sciences·M SatoR M Engelman
Jul 1, 1997·The British Journal of Ophthalmology·C H BuckleyC J O'Brien
Mar 4, 2014·Progress in Retinal and Eye Research·Dao-Yi YuEr-Ning Su
Dec 3, 2013·European Journal of Pharmacology·Chihiro Mayama
Oct 12, 2010·Progress in Retinal and Eye Research·Makoto Araie, Chihiro Mayama
Apr 29, 2006·Survey of Ophthalmology·Mona Pache, Josef Flammer
Apr 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·L FangManeli Mozaffarieh
Jun 8, 2013·The EPMA Journal·Josef FlammerAndreas J Flammer
Dec 4, 2012·The EPMA Journal·Katarzyna KonieczkaJosef Flammer
Jun 7, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Hanna Pitkänen, Ville Saarela
Feb 18, 1998·Clinical Pharmacology and Therapeutics·K StrennL Schmetterer
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mingkai LiXiaoxing Luo
May 1, 1997·Journal of Cardiovascular Pharmacology·J C RussellR M Amy
Mar 14, 2017·Case Reports in Otolaryngology·Serena ByrdJastin Antisdel
Jul 21, 2017·The EPMA Journal·Josef Flammer, Katarzyna Konieczka

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