Abstract
The effects of several calcium channel blockers (nifedipine, verapamil and diltiazem) on rat phrenic-hemidiaphragm preparations were studied. The calcium channel blockers were used either alone or associated with two aminoglycoside antibiotics, neomycin and streptomycin. All drugs investigated produced a concentration-dependent decrease in indirectly elicited diaphragmatic contractions. The order of potency was: verapamil greater than neomycin congruent to nifedipine greater than diltiazem greater than streptomycin. Moreover, neomycin-induced neuromuscular blockade was significantly increased by nifedipine (1 and 10 microM), verapamil (1 and 10 microM) and diltiazem (10 microM), whereas the streptomycin-induced neuromuscular blockade was increased only by nifedipine (1 and 10 microM) and verapamil (10 microM).
References
Feb 15, 1979·European Journal of Pharmacology·S J Publicover, C J Duncan
Jun 1, 1978·Anesthesiology·Y N SinghI G Marshall
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Jun 1, 1985·Neuropharmacology·R O EdesonR K Milne
Jan 1, 1972·Annual Review of Pharmacology·C Pittinger, R Adamson
Feb 1, 1982·British Journal of Anaesthesia·F G Standaert
Feb 1, 1983·Drugs·T T Zsotér, J G Church
Feb 5, 1982·European Journal of Pharmacology·D W Hay, R M Wadsworth
Dec 17, 1982·European Journal of Pharmacology·M FossetM Lazdunski
Nov 25, 1983·European Journal of Pharmacology·I J ReynoldsS H Snyder
May 1, 1983·Canadian Anaesthetists' Society Journal·B J KraynackJ Gintautas
Apr 1, 1984·Anesthesiology·N N DurantR L Katz
Jan 1, 1983·Anesthesia and Analgesia·N W LawsonJ Gintautas
Citations
May 1, 1994·Muscle & Nerve·I WirguinZ Argov
Jan 1, 1992·Journal of Neural Transmission. General Section·M OcañaJ M Baeyens
Jul 26, 1988·European Journal of Pharmacology·B De la Chapelle-Groz, P Athias
Jun 8, 1989·European Journal of Pharmacology·J BañosA Badia
Jan 1, 1989·General Pharmacology·D BustamanteC Paeile
Jan 1, 1990·General Pharmacology·J E BañosA Badia
Jan 1, 1992·Hearing Research·H HielJ M Aran
May 1, 1993·Hearing Research·S Takeuchi, P Wangemann
Jun 1, 1994·Hearing Research·J A López-EscámezA Campos
Feb 26, 2003·Cell Calcium·Andrei A Kochegarov
Apr 29, 2000·Acta Anaesthesiologica Scandinavica·J Poelaert, C Roosens
Apr 1, 1992·The Journal of General Physiology·T D ParsonsB M Salzberg
Feb 1, 1996·Anaesthesia·S Sekerci, M Tulunay
Feb 1, 1988·Pharmacology & Toxicology·J M Baeyens, E Del Pozo
Nov 1, 1987·British Journal of Pharmacology·R E Wachtel
Oct 1, 1989·Acta Anaesthesiologica Scandinavica·E del Pozo, J M Baeyens
Nov 1, 1989·Pharmacology & Toxicology·J M Baeyens, E Del Pozo
Jun 22, 1990·Pharmaceutisch Weekblad. Scientific Edition·R Janknegt
May 7, 2021·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Agam K RaoCarolina Luquez
Oct 1, 1989·Journal of Neuroscience Research·D DulonJ Schacht