PMID: 1203317Jan 1, 1975Paper

Effects of calcium ions on pyruvate kinase from human erythrocytes

Biochimie
J P FlikweertG E Staal

Abstract

Ca2+ ions have a biphasic effect on the allosteric pyruvate kinase (EC 2.7.1.40) from human erythrocytes: Ca2+ is an activator at low phosphoenolpyruvate (PEP) concentrations: at increased PEP concentrations Ca2+ behaves as an inhibitor. In the presence of ATP the same effect was observed and at low PEP concentrations Ca2+ ions can completely abolish the ATP inhibitory effect. At high Ca2+ concentrations there is a loss of the cooperativity towards PEP. The enzyme activated by fructose-1,6-diphosphate (FDP) is inhibited by Ca2+ ions at all concentrations of PEP tested. Mg2+ ions are not able to counteract the activation by Ca2+ ions at low PEP concentrations. The results are interpreted on the basis of the model of Monod.

References

Apr 1, 1969·The Journal of Physiology·H J Schatzmann, F F Vincenzi
May 1, 1968·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R HaeckelK H Wüster
Dec 4, 1972·European Journal of Biochemistry·F Gabrielli, S Baldi
Jan 13, 1971·Biochimica Et Biophysica Acta·G E StaalC Veeger
Oct 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·P CartierH Temkine
May 13, 1967·Nature·F L Bygrave
Nov 17, 1967·Biochemical and Biophysical Research Communications·T TanakaH Morimura
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX

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Citations

Jul 15, 1977·European Journal of Biochemistry·B Höjeberg, J Rydström

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