Effects of caloric restriction are species-specific.

Biogerontology
Robin J MockettR S Sohal

Abstract

This article addresses two questions: (1) 'can caloric restriction (CR) extend the life spans of all species of experimental animals', and (2) 'is CR likely to slow the human aging process and/or extend the human life span?' The answer to the first question is clearly 'no', because CR decreases the life span of the housefly, Musca domestica, and fails to extend the life span of at least one mouse strain. The answer to the second question is unknown, because human CR has not yet been shown either to increase or curtail the human life span. However, recent efforts to develop insect models of CR have been unsuccessful and/or relatively uninformative, so any insights regarding the relationship between CR and human aging are more likely to arise from studies of established, mammalian models of CR.

References

Jan 1, 1980·Experimental Gerontology·C J Driver, M J Lamb
Apr 16, 2002·Science·David J ClancyLinda Partridge
May 15, 2002·Current Biology : CB·Scott D PletcherLinda Partridge
Sep 5, 2002·Free Radical Biology & Medicine·Rajindar S SohalWilliam C Orr
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael J ForsterRajindar S Sohal
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Edward J Masoro
Jul 29, 2003·Aging Cell·James R CareyJane-Ling Wang
Sep 23, 2003·Science·William MairLinda Partridge
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T Michael CooperWilliam C Orr
Jun 24, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matthew D W PiperLinda Partridge
Nov 1, 2005·Mechanisms of Ageing and Development·Kyung-Jin Min, Marc Tatar
Nov 10, 2005·Nature Methods·Gil B CarvalhoSeymour Benzer

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Citations

Sep 14, 2006·Biogerontology·Alan R Hipkiss
Jun 9, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C Ruth ArcherJohn Hunt
May 9, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Genevieve S Young, James B Kirkland
Jan 15, 2009·The Journal of Nutrition·Rajindar S SohalMichael J Forster
Jan 15, 2014·The Proceedings of the Nutrition Society·Colin Selman
Jan 13, 2010·Mechanisms of Ageing and Development·Sarah HempenstallColin Selman
Oct 20, 2009·Experimental Gerontology·Stephanie S BauerfeindKlaus Fischer
Oct 11, 2008·Brain Research Reviews·Marwan MaaloufMark P Mattson
Oct 30, 2007·Ageing Research Reviews·Suresh I S Rattan
Sep 8, 2007·Mechanisms of Ageing and Development·Melissa FergusonRajindar S Sohal
Oct 18, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Eunsuk KimJeffry L Dudycha
Jun 20, 2014·Free Radical Biology & Medicine·Rajindar S Sohal, Michael J Forster
Aug 14, 2009·Current Biology : CB·Sri Devi NarasimhanHeidi A Tissenbaum
Jun 9, 2017·Nutrition Reviews·Morena MartucciAurelia Santoro
Nov 19, 2010·Aging·Vladimir N Anisimov

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