Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

Free Radical Biology & Medicine
L TianH Wei

Abstract

Decreased immune function associated with aging has been demonstrated in both humans and animals. We hypothesize that reactive oxygen species (ROS)-mediated damage to biological macromolecules may contribute to compromised immune response during aging. In this study, we compared the levels of lipid peroxidation and oxidatively modified proteins in plasma and splenocytes, and the mitogen-induced T lymphocyte proliferation in ad lib-fed (AL) and caloric restricted (CR) Fischer 344 x BNF1 male rats at the ages of 5, 18, and 31 months. The results show that AL rats exhibit an age-related decrease in proliferative response of splenic lymphocytes to phytohemagglutinin (PHA) and concanavalin A (Con A). This functional decline in T-lymphocytes during aging is inversely correlated to the levels of both lipid peroxidation and protein carbonyl in the plasma and splenic lymphocytes. Caloric restriction, however, can partially reverse the age-dependent decrease in T lymphocyte proliferation and significantly reduce lipid peroxidation and protein carbonyl contents in plasma and splenocytes. The above observations support the hypothesis that the age-associated declines in immune function are related to the oxidative modification of biological...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Aug 28, 1992·Science·E R Stadtman
Sep 1, 1992·Mutation Research·A M Hruszkewycz
Sep 1, 1992·Mutation Research·D Harman
Sep 1, 1992·Mutation Research·R S Sohal, U T Brunk
Sep 1, 1992·Mutation Research·G E HolmesH Bernstein
Jan 1, 1991·Annals of the New York Academy of Sciences·E J MasoroB P Yu
Sep 1, 1991·Mutation Research·M G Simic, D S Bergtold
Jun 1, 1989·Mechanisms of Ageing and Development·S Laganiere, B P Yu
Apr 1, 1988·Immunology Letters·K HishinumaS Kimura
Mar 1, 1987·Journal of Clinical Immunology·A R Hayward, M Herberger
Nov 1, 1993·Stem Cells·D N ErnstM V Hobbs
Jul 1, 1993·Experimental Gerontology·L SongW H Adler

❮ Previous
Next ❯

Citations

Jun 17, 2005·Journal of Physiology and Biochemistry·A I EsquifinoD P Cardinali
Apr 23, 2003·Experimental Cell Research·Dzung H Nguyen, Dennis D Taub
Jan 25, 2003·Experimental Gerontology·Jay A ZimmermanNorman Orentreich
Aug 17, 2000·The Journal of Infectious Diseases·M E GershwinC L Keen
Jul 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·W T CefaluR Weindruch
Oct 30, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·T GruneK Davies
Jan 27, 2007·Journal of Neuroinflammation·Ana I EsquifinoDaniel P Cardinali
Sep 17, 2009·Pflügers Archiv : European journal of physiology·Angelo AvogaroGian Paolo Fadini
Apr 13, 2000·Connective Tissue Research·C FornieriI P Ronchetti
Aug 16, 2011·Molecular Aspects of Medicine·John R Speakman, Sharon E Mitchell
Sep 16, 2009·Mechanisms of Ageing and Development·Beatriz CaballeroAna Coto-Montes
Mar 29, 2006·Veterinary Immunology and Immunopathology·Elizabeth H GreeleyMariangela Segre
Mar 11, 2006·Mechanisms of Ageing and Development·Ian Martin, Michael S Grotewiel
Mar 8, 2006·Free Radical Biology & Medicine·Katrin SchuesselAnne Eckert
Mar 21, 2003·Immunology and Allergy Clinics of North America·Rita B Effros
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Alicia J Kowaltowski
Aug 19, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Natalia PlatonovaLudmila Puchkova
Oct 12, 2007·Physiological Reviews·A J HulbertW A Buttemer
Apr 4, 2020·Antioxidants & Redox Signaling·Aleksandra Mladenovic DjordjevicEfstathios S Gonos
Jul 27, 2000·Annals of the New York Academy of Sciences·B J Merry
Dec 3, 2020·AIMS Neuroscience·Hannah P Priyanka, Rahul S Nair
Jun 15, 1997·Analytical Chemistry·A F HühmerC Schôneich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.