Effects of canagliflozin on cardiovascular risk factors in patients with type 2 diabetes mellitus

International Journal of Clinical Practice
Matthew J Budoff, John P H Wilding

Abstract

Cardiovascular disease is the most common cause of morbidity and mortality among people with type 2 diabetes mellitus (T2DM). The main contributors to cardiovascular risk in T2DM are chronic hyperglycaemia, reduced insulin sensitivity, hypertension and dyslipidaemia. Other cardiovascular risk factors include obesity and visceral adiposity, increased arterial stiffness and renal dysfunction. Results from clinical trials, including a long-term cardiovascular outcome study, have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors can provide multiple cardiometabolic benefits beyond glycaemic control including inducing mild osmotic diuresis, natriuresis and weight loss. This review article describes the effects of canagliflozin on cardiovascular risk factors based on results from its clinical development programme. This review is based on structured searches to identify literature related to the effects of canagliflozin on cardiovascular risk factors in patients with T2DM. Canagliflozin treatment has been shown to provide glycaemic improvements as well as reductions in blood pressure and body weight across a broad range of patients with T2DM, including those with elevated cardiovascular risk. Other observed effects of can...Continue Reading

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Tuba M AnsaryAkira Nishiyama
Feb 27, 2020·Journal of Atherosclerosis and Thrombosis·Arief RahadianMasataka Sata
May 26, 2018·Expert Opinion on Pharmacotherapy·Nobuya InagakiHiroaki Iijima
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Methods Mentioned

BETA
amputations
amputation

Clinical Trials Mentioned

NCT01989754
NCT02065791

Software Mentioned

CANVAS

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