Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Rudolf MoldzioWolf-Dieter Rausch

Abstract

Cannabinoids derived from Cannabis sativa demonstrate neuroprotective properties in various cellular and animal models. Mitochondrial impairment and consecutive oxidative stress appear to be major molecular mechanisms of neurodegeneration. Therefore we studied some major cannabinoids, i.e. delta-9-tetrahydrocannabinolic acid (THCA), delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in mice mesencephalic cultures for their protective capacities against 1-methyl-4-phenyl pyridinium (MPP(+)) toxicity. MPP(+) is an established model compound in the research of parkinsonism that acts as a complex I inhibitor of the mitochondrial respiratory chain, resulting in excessive radical formation and cell degeneration. MPP(+) (10 μM) was administered for 48 h at the 9th DIV with or without concomitant cannabinoid treatment at concentrations ranging from 0.01 to 10 μM. All cannabinoids exhibited in vitro antioxidative action ranging from 669 ± 11.1 (THC), 16 ± 3.2 (THCA) to 356 ± 29.5 (CBD) μg Trolox (a vitamin E derivative)/mg substance in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Cannabinoids were without effect on the morphology of dopaminergic cells stained by tyrosine hydroxylase (TH) immunoreaction. THC caused a dos...Continue Reading

References

May 1, 1993·Journal of Neuropathology and Experimental Neurology·M S PollanenC Bergeron
Jan 22, 1993·The Journal of Comparative Neurology·L A MatsudaS J Lolait
Nov 15, 1996·Science·M H PolymeropoulosR C Duvoisin
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·A J HampsonD Wink
Apr 15, 1999·Annual Review of Neuroscience·C W Olanow, W G Tatton
Jul 9, 2004·Annals of the New York Academy of Sciences·G GilleW-D Rausch
Aug 7, 2004·Brain Research. Brain Research Reviews·Yue HuangGlenda Halliday
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sang R KimByung K Jin
Jul 20, 2005·Mini Reviews in Medicinal Chemistry·Inés Díaz-Laviada, Lidia Ruiz-Llorente
Jun 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Silvia MarinelliNicola B Mercuri
Jul 20, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Teresa IuvoneUNKNOWN Endocannabinoid Research Group
Jun 3, 2008·British Journal of Anaesthesia·R D Hosking, J P Zajicek
Dec 18, 2008·Phytotherapy Research : PTR·Khaled RadadWolf-Dieter Rausch
Jun 27, 2009·Archives of Pharmacal Research·Bang Shil ChoiSang Soo Sim

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Citations

Apr 16, 2014·Bioorganic & Medicinal Chemistry·Sumner H Burstein
Nov 12, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Neife Aparecida Guinaim SantosAntônio Cardozo Santos
Apr 19, 2015·Molecular Neurodegeneration·Sandeep Vasant More, Dong-Kug Choi
Aug 31, 2017·British Journal of Pharmacology·Xavier NadalEduardo Muñoz
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Liwei WuJianye Wu
Jul 2, 2020·British Journal of Pharmacology·Nicole L StoneSaoirse E O'Sullivan
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martyna Zagórska-DziokZofia Nizioł-Łukaszewska
Dec 3, 2020·International Journal of Molecular Sciences·Fatema Yeasmin, Hyong Woo Choi
Sep 4, 2021·Environmental Science and Pollution Research International·Muzammal RehmanGang Deng

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