Effects of canrenone on aorta and right ventricle of the rat

Journal of Cardiovascular Pharmacology
G CargnelliS Bova

Abstract

Canrenone is a major active metabolite of spironolactone and, in addition to the antimineralocorticoid effect, shares with the parent compound the action as a partial agonist with respect to ouabain on the Na+-K+ ATPase. We have investigated whether canrenone, through its action on Na+-K+ ATPase, reverses rat aorta contractions induced by ouabain and has vasorelaxant properties unrelated to its interaction with ouabain. Contractile responses of endothelium-deprived aorta to 1 mM ouabain, 0.1 microM phenylephrine, 10 microM serotonin, and 60 mM K+ were relaxed by canrenone (50-250 microM), with maximum inhibitions of 85.3%, 55.3%, 56.7%, and 64.2%, respectively. Canrenone shifted to the right the concentration-response curve for Ca2+ in depolarized aorta and did not affect the response to 10 mM caffeine. In rat right ventricular strips driven at 0.1 Hz, canrenone exerted negative inotropic effect. The relaxation of ouabain-induced contraction may be due, at least in part, to an interaction between canrenone and ouabain on the Na+-K+ ATPase. Inhibition of calcium entry through calcium channels either in aorta or ventricles is the most parsimonious hypothesis of mechanism underlying the effect of canrenone on contractile responses...Continue Reading

References

May 1, 1977·Clinical Pharmacology and Therapeutics·L RamsayI Harrison
Jun 19, 1990·The American Journal of Cardiology·J Mironneau
Jun 19, 1990·The American Journal of Cardiology·D L Clement
Jan 1, 1988·Journal of Cardiovascular Pharmacology·M de MendonçaR Garay
May 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·R P GarayJ P Abitbol
Nov 1, 1988·European Journal of Pharmacology·H KarakiK Murakami
Mar 1, 1988·British Journal of Pharmacology·S BovaS Luciani
Nov 1, 1987·British Journal of Pharmacology·C DacquetP Pacaud
May 1, 1993·Journal of Molecular and Cellular Cardiology·C G BrillaK T Weber
Jan 21, 1993·The American Journal of Cardiology·D C SchohnB C Pelletier
May 21, 1999·British Journal of Clinical Pharmacology·A D Struthers
Sep 15, 1999·Lancet·A M Richards, M G Nicholls
Jul 27, 2000·Journal of Cellular Physiology·J A CarvajalC P Weiner

❮ Previous
Next ❯

Citations

Nov 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Wenxia Chai, A H Jan Danser
Apr 19, 2005·British Journal of Pharmacology·Wenxia ChaiA H Jan Danser
Apr 25, 2015·Advances in Chronic Kidney Disease·John M Hamlyn, Paolo Manunta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.