PMID: 8448594Feb 1, 1993Paper

Effects of capsaicin and 5-HT3 antagonists on 5-hydroxytryptamine-evoked release of calcitonin gene-related peptide in the guinea-pig heart

British Journal of Pharmacology
M TramontanaP Geppetti

Abstract

1. The effect of 5-hydroxytryptamine (5-HT) on the release of calcitonin gene-related peptide (CGRP) was studied directly in the isolated perfused heart and indirectly in the isolated left atria of guinea-pig. 2. 5-HT injection into the guinea-pig isolated and perfused heart evoked a dose-dependent (1-100 microM) release of CGRP-like immunoreactivity (LI) that was abolished by in vitro pretreatment with capsaicin and was not affected by indomethacin. 3. Chlorophenyldiguanide (CPD, 100 microM), but not 8-hydroxy-dipropylaminotetralin (8-OH-DPAT, 100 microM), sumatriptan (100 microM) or 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI, 100 microM) evoked a release of CGRP-LI. Ondansetron (10 microM) or ICS205-930 (20 microM) completely abolished the 5-HT (100 microM)-evoked CGRP-LI release. 4. In the isolated electrically driven left atria of the guinea-pig 5-HT (1-10 microM) and CPD (3-100 microM) produced a positive inotropic response, which was abolished by capsaicin pretreatment. 8-OH-DPAT (10 microM) and DOI (10 microM) were inactive. Ondansetron inhibited the response to 5-HT with a pA2 of 6.50 (CL 6.08-6.91). 5. It is concluded that 5-HT causes a release of CGRP in the whole heart and a positive inotropic response in the...Continue Reading

References

Jan 1, 1979·Reviews of Physiology, Biochemistry and Pharmacology·P Thorén
Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Fozard, A T Ali
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Oct 1, 1991·Journal of Neuroscience Research·H Vedder, U Otten
May 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·G S BaxterD E Clarke
Aug 1, 1990·British Journal of Pharmacology·A J KaumannM J Brown
Oct 24, 1989·European Journal of Pharmacology·J Giordano, L V Rogers
Jun 1, 1988·British Journal of Pharmacology·A ButlerM B Tyers
Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·A Franco-Cereceda, J M Lundberg
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jul 1, 1991·Trends in Cardiovascular Medicine·H E ConnorW Feniuk

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Citations

Aug 19, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Carlos M Villalón, David Centurión
Nov 13, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrich GergsStephanie Läer
Jan 12, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrich GergsJoachim Neumann
Dec 1, 1994·General Pharmacology·N ErinS Oktay
Apr 29, 1998·British Journal of Pharmacology·S LäerJ Neumann
May 11, 2012·PloS One·Eduardo Martínez-MartínezGabriel Gutiérrez-Ospina
Mar 1, 2002·Journal of Basic and Clinical Physiology and Pharmacology·C KüçükhüseyinD O Yillar
Mar 1, 2012·Molecular and Cellular Biochemistry·Klaus PönickeJoachim Neumann
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jennelle Durnett Richardson, Michael R Vasko

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