PMID: 2485875Oct 23, 1989Paper

Effects of capsaicin on myenteric neurons of the guinea pig ileum

Neuroscience Letters
M Takaki, S Nakayama

Abstract

The effects of capsaicin on the electrophysiological behavior of myenteric neurons were investigated with intracellular recording techniques in the isolated guinea pig ileum. Capsaicin evoked a marked long-lasting slow depolarization associated with increased input resistance, during which the cells spiked repeatedly or displayed anodal break excitation. Capsaicin did not produce the slow depolarizing action on myenteric neurons in Ca2(+)-free media (with 0.1 mM ethylenediaminetetraacetic acid) or in the mesenteric denervated ileum. This action of capsaicin on myenteric neurons seems to be mediated via a release of substance P, possibly from sensory nerve endings.

References

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Citations

Sep 4, 1990·European Journal of Pharmacology·M TakakiS Nakayama
May 4, 1995·European Journal of Pharmacology·R PatacchiniC A Maggi
Feb 14, 1998·Progress in Neurobiology·J B FurnessJ C Bornstein
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P Holzer
Nov 29, 2002·The Journal of Physiology·Nick J SpencerTerence K Smith
Feb 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Simon J H BrookesVladimir P Zagorodnyuk
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J NuglischJ Krieglstein
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paula MiceliStephen Vanner
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe

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