PMID: 6188693May 1, 1983Paper

Effects of captopril and enalapril on regional vascular resistance and reactivity in spontaneously hypertensive rats

Hypertension
C RicherJ F Giudicelli

Abstract

The present study compares the effects of short-term treatments with captopril and enalapril, administered in equipotent antihypertensive doses, on the regional vascular resistances and on the regional vascular responsiveness to vasopressor agents of adult spontaneously hypertensive rats (SHRs). Three groups of animals were treated by gavage with captopril (100 mg/kg), enalapril (25 mg/kg), or distilled water for 8 days. Arterial blood pressure (BP), heart rate (HR), plasma renin concentration (PRC), and plasma converting-enzyme activity (CEA) were measured. Cardiac index (CI), total peripheral resistance (PR), and organ flow distribution were determined using microspheres. Renal and mesenteric vascular responsiveness to vasopressor agents was evaluated by continuous measurement of renal and mesenteric blood flows with miniaturized pulsed Doppler flow probes. Data showed that in the anesthetized SHR the two drugs induced similar reductions in BP, PR, and HR, without affecting CI. They simultaneously produced a strong converting-enzyme inhibition as evidenced by the suppression of angiotensin I effects accompanied by a potentiation of angiotensin II responses, a reduction in CEA, and an increase in PRC. Organ flows were similarl...Continue Reading

References

Oct 1, 1979·British Journal of Pharmacology·G M Drew, S B Whiting
May 4, 1978·The New England Journal of Medicine·H GavrasD N McKinstry
Dec 7, 1979·European Journal of Pharmacology·R A Ferrone, M J Antonaccio
Mar 1, 1976·The American Journal of Physiology·K NishiyamaE D Frohlich
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Jul 1, 1972·Journal of Applied Physiology·M A Pfeffer, E D Frohlich
Nov 1, 1981·Journal of Cardiovascular Pharmacology·J C AldigierJ Menard
Apr 21, 1982·The American Journal of Cardiology·T SarutaK Kondo
Apr 21, 1982·The American Journal of Cardiology·M J Antonaccio, M McGill
Apr 8, 1982·European Journal of Pharmacology·C RicherJ F Giudicelli
Nov 1, 1981·Hypertension·M J AntonaccioD Kotler
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·R A FerroneM J Antonaccio
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·J F GiudicelliC Richer
Dec 1, 1980·British Journal of Clinical Pharmacology·D CasellasC Chevillard

Citations

Apr 3, 1999·British Journal of Pharmacology·K L LiuJ Sassard
May 31, 1984·The American Journal of Medicine·A C SimonM E Safar
Oct 1, 1987·The American Journal of Cardiology·K Przyklenk, R A Kloner
Sep 1, 1985·British Journal of Clinical Pharmacology·J F GiudicelliD Jacolot
Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·G R Bolt, P R Saxena
Feb 1, 1986·American Heart Journal·K AndoK Yamashita
Mar 1, 1986·Journal of the American College of Cardiology·P H VlassesR K Ferguson
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·H YokoyamaH Fujiwara
Sep 1, 1983·Hypertension·J I Drayer, M A Weber

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