Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression

Canadian Journal of Physiology and Pharmacology
Charles BlaisAlbert Adam

Abstract

The purpose of this study was to evaluate and compare the effects of simultaneous angiotensin-converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP) inhibition by the vasopeptidase inhibitor omapatrilat (10 and 40 mg x kg(-1) x day(-1)) with those of the selective ACE inhibitor captopril (160 mg x kg(-1) x day(-1)) on survival, cardiac hemodynamics, and cytokine mRNA expression in left ventricular (LV) tissues 4 days after myocardial infarction (MI) in rats. The effects of the co-administration of both B1 and B2 kinin receptor antagonists (2.5 mg x kg(-1) x day(-1) each) with and without omapatrilat were also evaluated to assess the role of bradykinin (BK) during this post-MI period. Both omapatrilat and captopril treatments improve early (4 days) post-MI survival when started 4 h post-MI. The use of kinin receptor antagonists had no significant effect on survival in untreated MI rats and omapatrilat-treated MI rats. This improvement in survival with omapatrilat and captopril is accompanied by a reduced LV end-diastolic pressure (LVEDP) and pulmonary congestion. The use of kinin receptor antagonists had little effect on cardiac hemodynamics or morphologic measurements. Acute MI significantly increased the expression of c...Continue Reading

References

Apr 1, 1979·Circulation Research·N G Levinsky
Apr 1, 1979·Circulation Research·M A PfefferE Braunwald
Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Jun 1, 1992·Journal of Molecular and Cellular Cardiology·U IkedaK Shimada
Sep 1, 1992·The Journal of Clinical Investigation·B P GiroirB Beutler
Jan 1, 1990·Annals of the New York Academy of Sciences·W CasscellsM Sporn
May 1, 1989·Journal of Internal Medicine·C P Maury, A M Teppo
Jan 1, 1988·Growth Factors·N L ThompsonM B Sporn
Jul 1, 1985·Circulation Research·J M PfefferE Braunwald
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Sep 1, 1994·Cardiovascular Research·Y SunK T Weber
Dec 1, 1996·Cytokine & Growth Factor Reviews·D L Mann
Aug 1, 1997·Annals of Medicine·K J Pulkki
Mar 7, 1998·American Heart Journal·A Blum, H Miller
Apr 8, 1998·The American Journal of Physiology·D R Meldrum
May 13, 1998·Circulation·N J Brown, D E Vaughan
Oct 26, 1999·Cardiovascular Research·S SasayamaY Kihara
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Apr 26, 2000·British Journal of Pharmacology·C TschöpeT Walther
Sep 26, 2000·Molecular Genetics and Metabolism·P J LijnenR H Fagard
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·S P Zhao, X M Xie

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Citations

Mar 25, 2009·Biochemical and Biophysical Research Communications·Dongxia GeHuaiqing Chen
Dec 18, 2003·British Journal of Clinical Pharmacology·Matthew I WorthleyStephen G Worthley
Jun 6, 2006·Cytokine & Growth Factor Reviews·Dimitris TousoulisChristodoulos Stefanadis
Sep 14, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Giuseppe A Sagnella
Mar 29, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Nathalie LapointeJean-Lucien Rouleau

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