Effects of captopril on blood pressure, electrolytes, and certain hormones in hypertension

Clinical Pharmacology and Therapeutics
L GuillevinP Corvol

Abstract

Short-term hypertensive and hormonal effects of captopril were studied in 26 hypertensive patients. Blood pressure (BP) and heart rate were recorded in subjects in the supine position 1 hr before and 3 hr after an oral dose of 1 mg/kg. Urinary, plasma electrolytes, plasma renin activity (PRA), and plasma aldosterone (PA) were determined before and after the test. It was verified, in a preliminary investigation involving 5 patients, that a placebo did not alter the measured parameters. Captopril decreased mean arterial pressure (mean ABP +/- SD) from 128 +/- 2.5 to 108.5 +/- 2.6 mm Hg (p less than 0.001); the maximum decrease was between 30 and 180 min. No changes in heart rate or plasma electrolytes were noted. PRA increased after captopril from 2.29 +/- 0.96 to 3.13 +/- 1.25 and to 4.11 +/- 1.87 at 1 hr and 3 hr (p less than 0.05). There was a correlation between PRA in standing subjects before captopril and decrease in mean ABP (r = 0.59, p less than 0.01). The best correlation was between the decrease in mean ABP and the maximum increase in PRA after captopril (r = 0.69). A good correlation was found between mean ABP and PRA 3 hr after captopril (r = 0.62). Correlation coefficients between decrease in mean ABP and either pre...Continue Reading

Citations

Mar 1, 1985·British Journal of Clinical Pharmacology·W R McNabbA F Lant
Oct 1, 1989·Journal of Clinical Pharmacology·F H NoormohamedA F Lant
Nov 1, 1981·Clinics in Endocrinology and Metabolism·S A Atlas, D B Case

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