Effects of carbamazepine on cortisol levels and behavioral responses to stress in the fish Jenynsia multidentata

Physiology & Behavior
Emilia CalcagnoMaría de los Ángeles Bistoni

Abstract

Carbamazepine (CBZ) is an anticonvulsant drug, prescribed worldwide for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia, which has been frequently detected in aquatic environments. The objective of this study was to analyze if CBZ modifies scototaxis and shoaling behaviors and/or whole-body cortisol levels of the one-sided livebearing fish Jenynsia multidentata under stress condition. Female adults of J. multidentata were exposed to 0, 10, 50 and 200μgCBZ/L during 14days. After CBZ exposure, fish were subjected to restraint stress during 15min. Control animals were not exposed to CBZ or stress. In the light/dark preference test (scototaxis), the individuals under acute restraint stress (without CBZ) exhibited a significant increase in the mean speed and in the time spent both in the light compartment and in the bottom of the tank with respect to controls. They also showed a tendency to stay longer frozen in the light compartment. Fish exposed to 10 and 50μgCBZ/L showed a significant reduction in mean speed compared to stressed fish without CBZ. A reduction in the time spent in the bottom of the tank was also observed in fish exposed to 10μgCBZ/L. Fish exposed to 200μgCBZ/L showed a decreasing tendency in al...Continue Reading

References

May 7, 1998·Chemosphere·B Halling-SørensenS E Jørgensen
Sep 13, 2001·Harvard Review of Psychiatry·O A De León
Apr 3, 2002·Neurochemical Research·António F AmbrósioArsélio P Carvalho
Apr 15, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ehab S El DesokyJean-Pascal Siest
Nov 1, 2005·Aquatic Toxicology·Karl FentDaniel Caminada
Oct 20, 2006·Physiology & Behavior·Edward D LevinDaniel T Cerutti
Aug 3, 2007·Toxicon : Official Journal of the International Society on Toxinology·Philip Pommier, Luc de Haro
Nov 29, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ho-Joo LeeRichard P Bazinet
Nov 4, 2008·Animal Behaviour·Raymond E EngeszerDavid M Parichy
Jun 23, 2009·Behavioural Brain Research·Rupert J EganAllan V Kalueff
Oct 10, 2009·Chemosphere·Vânia Calisto, Valdemar I Esteves
Dec 17, 2009·Behavioural Brain Research·Jonathan CachatAllan V Kalueff
Feb 6, 2010·Nature Protocols·Caio MaximinoSilvio Morato
Mar 17, 2010·Critical Reviews in Toxicology·Jenna CorcoranCharles R Tyler
Jun 1, 2010·Behavioural Brain Research·Caio MaximinoAmauri Gouveia
Jun 3, 2010·Archives of Disease in Childhood·W HöglerM Rauchenzauner
Jun 15, 2010·Behavioural Brain Research·Danielle L ChampagneMichael K Richardson
Oct 30, 2010·Nature Protocols·Jonathan CachatAllan V Kalueff
Dec 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam StewartAllan V Kalueff
Feb 15, 2011·Neuroscience and Biobehavioral Reviews·J M KoolhaasE Fuchs
Jun 21, 2011·Aquatic Toxicology·Nasim ReyhanianInger Porsch Hällström
Sep 7, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriele GhisleniCarla D Bonan
Dec 7, 2011·Aquatic Toxicology·Malin C Celander
Dec 20, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K V CookS J Cooke
Aug 14, 2012·Archives of Environmental Contamination and Toxicology·Tamara MaggioniMaría Valeria Amé
Aug 21, 2012·Ecotoxicology and Environmental Safety·Santos N GarciaDuane B Huggett
Dec 12, 2012·Behavioural Brain Research·Noam MillerRobert Gerlai
Dec 12, 2012·Bulletin of Environmental Contamination and Toxicology·Yanina ElorriagaAlicia E Ronco
Jan 1, 2013·General and Comparative Endocrinology·Christina SørensenØyvind Øverli
Apr 18, 2013·Zebrafish·Allan V KalueffUNKNOWN Zebrafish Neuroscience Research Consortium
Sep 14, 2013·The Journal of Experimental Biology·Manuel GestoJesús M Míguez
Dec 4, 2013·The Science of the Total Environment·María Eugenia ValdésDaniel Alberto Wunderlin
Dec 20, 2013·The Journal of Experimental Biology·Patricia M Schulte
Jan 15, 2014·Journal of Environmental Management·Armin ZenkerMario Carere
May 6, 2014·Journal of Neuroscience Methods·Robert Gerlai
May 13, 2014·Trends in Cognitive Sciences·Redouan BsharyAlexander L Vail
May 14, 2014·Behavioural Brain Research·Erika M CaramilloDavid J Echevarria
Aug 16, 2014·Fish & Shellfish Immunology·Gino NardocciRicardo Fernández
Dec 4, 2014·Epileptic Disorders : International Epilepsy Journal with Videotape·Frank J E Vajda, Mervyn J Eadie

❮ Previous
Next ❯

Citations

Aug 9, 2015·The Science of the Total Environment·Leonardo LupiDaniel A Wunderlin
Feb 13, 2021·Environmental Science and Pollution Research International·Jessica Andrea Albañil SánchezCamila De Gaspar Martinez Martins
Jul 3, 2021·International Journal of Environmental Research and Public Health·Alessandro AtzeiEllen V S Hessel
Aug 9, 2019·Environmental Science & Technology·Shamaila FrazJoanna Y Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.