PMID: 2492224Jan 1, 1989Paper

Effects of carbamazepine on pituitary responsiveness to luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, and metoclopramide in epileptic patients

Epilepsia
J I T IsojärviA J Pakarinen

Abstract

Pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone (TRH), and metoclopramide (MC) was studied in 40 epileptic patients (24 men and 16 women) receiving carbamazepine (CBZ) treatment and in 29 (20 men and 9 women) untreated epileptic patients. Mean basal concentration of serum LH was significantly lower in the CBZ-treated female patients than in untreated female patients. The response of LH to LH-RH was also blunted in CBZ-treated female patients. No differences were found in basal or stimulated LH levels between the two groups of male patients. Nevertheless, the mean basal concentration of serum prolactin (PRL) was lower and the response of PRL to TRH was higher in male patients treated with CBZ. No differences were found in serum levels of follicle-stimulating hormone (FSH) or in responses of FSH to LH-RH between the CBZ-treated and untreated patients. These results indicate that CBZ has effects on pituitary responsiveness.

References

Apr 1, 1986·Archives of Neurology·A G HerzogN Geschwind
Sep 1, 1985·Clinical Endocrinology·R D ElwesD R London
Aug 1, 1974·Metabolism: Clinical and Experimental·T Yamaji
Dec 1, 1984·Epilepsia·E RodinJ Gilroy
Feb 1, 1981·Acta Neurologica Scandinavica·R E StrandjordS I Johannessen
Jul 1, 1980·The American Journal of Psychiatry·J C Ballenger, R M Post

❮ Previous
Next ❯

Citations

Jul 1, 1991·Epilepsy Research·J I IsojärviV V Myllylä
Sep 1, 1996·Seizure : the Journal of the British Epilepsy Association·M C Walker, J W Sander
Nov 13, 2001·British Journal of Pharmacology·K TamuraH Kogo
May 13, 1998·Epilepsia·J I IsojärviV V Myllylä
Jan 6, 2011·Epilepsia·Alberto VerrottiFrancesco Chiarelli
Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·U LindbomD E Andersson
Jun 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C NappiL Bilo
Feb 23, 2011·Reproductive Toxicology·Alberto VerrottiGian Mario Tiboni
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Bryan R Haugen
Mar 1, 2006·Pediatric Neurology·Jennifer Miller, Paul Carney
Jun 6, 2014·The Lancet. Diabetes & Endocrinology·Rosa Maria ParagliolaRoberto Salvatori
Dec 3, 2009·Expert Review of Neurotherapeutics·Alberto VerrottiFrancesco Chiarelli
Jun 14, 2003·Molecular Endocrinology·Laurie B CookPatricia M Hinkle
Dec 1, 2007·Vascular Medicine·Scott HaugenWilliam R Hiatt
Jan 24, 2012·Bulletin of Experimental Biology and Medicine·P M LarionovL M Nepomnyashchikh
Jun 18, 2019·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Ehrin J ArmstrongPeter A Schneider
Jun 5, 1999·Journal of Internal Medicine·G Kretschmer, T J Hölzenbein
Oct 19, 2004·Vascular and Endovascular Surgery·Kevin CaseySamuel R Money
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiromi KoikeYasufumi Kaneda
Jun 26, 2013·Journal of Internal Medicine·M A Lambert, J J F Belch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.