PMID: 8592826Oct 1, 1995Paper

Effects of carbaryl on the rat's male reproductive system

Veterinary and Human Toxicology
N PantS P Srivastava

Abstract

Carbaryl was orally administered to male albino rats at 50 mg or 100 mg carbaryl/kg body weight 5 d/w for 90 d. A significant decrease in weight gain was observed at the high dosage after 60 d. Although no significant changes in the weight of testes, epididymides and accessory sex organs occurred, moderate to marked histopathological changes in the testes were seen at both dosage levels. Testicular enzymes associated with post-meiotic spermatogenic cells (sorbitol dehydrogenase) decreased, while lactate dehydrogenase increased concomitant with the observed degeneration of spermatogenic cells. Enzymes associated with pre-meiotic spermatogenic cells or Sertoli cells (gamma-glutamyl transpeptidase) increased, while glucose-6-phosphate dehydrogenase decreased. These effects were dose related and associated with declines in epididymal sperm count and percent sperm motility and increased abnormal sperm morphology.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Ratna Pandey, S P Singh
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
R PandeyS C Srivastava
Indian Journal of Experimental Biology
S SrivastavaS C Srivastava
© 2021 Meta ULC. All rights reserved