PMID: 7678844Feb 1, 1993

Effects of carbon monoxide exposure in patients with documented cardiac arrhythmias

Journal of the American College of Cardiology
T E DahmsB R Chaitman


This study was designed to determine whether carbon monoxide has proarrhythmic effects at rest and during upright exercise in patients with myocardial ischemia and moderate baseline ectopic activity. Exposure of patients with documented myocardial ischemia to low levels of carboxyhemoglobin (COHb) alters the myocardial response to exercise. Anecdotal reports from patients with myocardial ischemia have noted the development of arrhythmias related to carbon monoxide exposure. Increased frequency of arrhythmias related to carbon monoxide exposure in patients performing supine bicycle exercise has been recently reported. Twenty-eight nonsmoking men and five nonsmoking women with documented coronary artery disease and a minimum of 30 ventricular ectopic beats/h over a 20-h period were studied. Subjects were exposed in a randomized double-blind fashion to either room air or sufficient carbon monoxide to elevate their COHb concentration to 3% or 5% in 1 h, followed by a maintenance exposure to carbon monoxide. The subjects then left the laboratory and resumed their normal daily activity to determine changes in ventricular ectopic beats after carbon monoxide exposure. There was no significant change in the frequency of single ventricul...Continue Reading


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Related Concepts

Atmosphere Exposure Chambers
Carbon Monoxide
Carboxyhemoglobin C
Double-Blind Method
Cardiopulmonary Exercise Test
Premature Cardiac Complex
Exercise, Isometric
Holter Electrocardiography
Myocardial Ischemia

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