PMID: 7678844Feb 1, 1993

Effects of carbon monoxide exposure in patients with documented cardiac arrhythmias

Journal of the American College of Cardiology
T E DahmsB R Chaitman

Abstract

This study was designed to determine whether carbon monoxide has proarrhythmic effects at rest and during upright exercise in patients with myocardial ischemia and moderate baseline ectopic activity. Exposure of patients with documented myocardial ischemia to low levels of carboxyhemoglobin (COHb) alters the myocardial response to exercise. Anecdotal reports from patients with myocardial ischemia have noted the development of arrhythmias related to carbon monoxide exposure. Increased frequency of arrhythmias related to carbon monoxide exposure in patients performing supine bicycle exercise has been recently reported. Twenty-eight nonsmoking men and five nonsmoking women with documented coronary artery disease and a minimum of 30 ventricular ectopic beats/h over a 20-h period were studied. Subjects were exposed in a randomized double-blind fashion to either room air or sufficient carbon monoxide to elevate their COHb concentration to 3% or 5% in 1 h, followed by a maintenance exposure to carbon monoxide. The subjects then left the laboratory and resumed their normal daily activity to determine changes in ventricular ectopic beats after carbon monoxide exposure. There was no significant change in the frequency of single ventricul...Continue Reading

References

Jan 1, 1976·Archives of Environmental Health·D A DeBiasW V Harrer
Mar 15, 1991·Annals of Internal Medicine·M AkhtarP J Troup
Sep 1, 1990·Annals of Internal Medicine·D S ShepsM N Ballenger
Nov 1, 1972·Annals of Internal Medicine·W S AronowB Imparato
Jan 1, 1974·Journal of Clinical Pharmacology·B KaulD E Hutcheon
Dec 20, 1968·Science·J R Goldsmith, S A Landaw
Nov 1, 1983·Journal of the American College of Cardiology·I P Panidis, J Morganroth

Citations

Jul 1, 1996·Archives of Environmental Health·D A Leaf, M T Kleinman
Jun 21, 2013·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Suleyman TurediAbdulkadir Gunduz
May 1, 2001·Journal of Toxicology. Clinical Toxicology·C GandiniL Manzo
Sep 15, 2016·Environmental Science and Pollution Research International·Emanuel Tirosh, Izhak Schnell
Jul 11, 2012·European Journal of Preventive Cardiology·Alessandra D'AlessandroAndreas Goette
Oct 6, 2015·Research in Cardiovascular Medicine·Siyavash JoukarSoodabe Ghorbani Shahrbabaki

Related Concepts

Atmosphere Exposure Chambers
Carbon Monoxide
Carboxyhemoglobin C
Double-Blind Method
Cardiopulmonary Exercise Test
Premature Cardiac Complex
Randomization
Exercise, Isometric
Holter Electrocardiography
Myocardial Ischemia

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