Effects of cardiac energy efficiency in diastolic heart failure: assessment with positron emission tomography with 11C-acetate

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Shinji HasegawaJun Hatazawa

Abstract

Diastolic heart failure (DHF) has become a high social burden, and its major underlying cardiovascular disease is hypertensive heart disease. However, the pathogenesis of DHF remains to be clarified. This study aimed to assess the effects of cardiac energy efficiency in DHF patients. (11)C-Acetate positron emission tomography and echocardiography were conducted in 11 DHF Japanese patients and 10 normal volunteers. The myocardial clearance rate of radiolabeled (11)C-acetate was measured to calculate the work metabolic index (WMI), an index of cardiac efficiency. The ratio of peak mitral E wave velocity to peak early diastolic septal myocardial velocity (E/e') was calculated to assess left ventricular (LV) filling pressure. The LV mass index was greater and the mean age was higher in the DHF patients than in the normal volunteers. There was no difference in WMI between the two groups. However, WMI varied widely among the DHF patients and was inversely correlated with E/e' (r=-0.699, p=0.017). In contrast, there was no correlation in the normal volunteers. In conclusion, the inefficiency of energy utilization is not a primary cause of diastolic dysfunction or DHF, and cardiac efficiency may not affect diastolic function in normal ...Continue Reading

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Citations

Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhiro YamamotoToshiaki Mano
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mayu NishioKazuhiro Yamamoto
Jan 15, 2017·Cardiovascular Diabetology·Jason Kar Sheng LewRajesh Katare
Mar 3, 2010·Circulation. Cardiovascular Imaging·Benjamin J W ChowTerrence D Ruddy

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