Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia

American Journal of Physiology. Gastrointestinal and Liver Physiology
Stephan M JakobJukka Takala

Abstract

Insufficient cardiac preload and impaired contractility are frequent in early sepsis. We explored the effects of acute cardiac preload reduction and dobutamine on hepatic arterial (Qha) and portal venous (Qpv) blood flows during endotoxin infusion. We hypothesized that the hepatic arterial buffer response (HABR) is absent during preload reduction and reduced by dobutamine. In anesthetized pigs, endotoxin or vehicle (n = 12, each) was randomly infused for 18 h. HABR was tested sequentially by constricting superior mesenteric artery (SMA) or inferior vena cava (IVC). Afterward, dobutamine at 2.5, 5.0, and 10.0 μg/kg per minute or another vehicle (n = 6, each) was randomly administered in endotoxemic and control animals, and SMA was constricted during each dose. Systemic (cardiac output, thermodilution) and carotid, splanchnic, and renal blood flows (ultrasound Doppler) and blood pressures were measured before and during administration of each dobutamine dose. HABR was expressed as hepatic arterial pressure/flow ratio. Compared with controls, 18 h of endotoxin infusion was associated with decreased mean arterial blood pressure [49 ± 11 mmHg vs. 58 ± 8 mmHg (mean ± SD); P = 0.034], decreased renal blood flow, metabolic acidosis, an...Continue Reading

References

Aug 1, 1991·Critical Care Medicine·G R DoglioG Gutierrez
Mar 1, 1985·The American Journal of Physiology·W W LauttM S d'Almeida
Sep 1, 1989·Canadian Journal of Physiology and Pharmacology·W W Lautt, J E McQuaker
Feb 1, 1995·Clinical Science·H F GoodeN R Webster
Apr 1, 1995·Journal of Applied Physiology·T AyuseJ L Robotham
Mar 1, 1995·The American Journal of Physiology·T AyuseJ L Robotham
Jun 1, 1996·Critical Care Medicine·I TsuneyoshiN Yoshimura
Jan 1, 1996·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Y GundersenA O Aasen
Mar 1, 1997·The American Journal of Physiology·S M HollenbergJ E Parrillo
Apr 1, 1997·The Surgical Clinics of North America·J D RosenblumL B Schwartz
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·D De BackerJ L Vincent
Mar 24, 1999·The Journal of Physiology·A RasmussenN H Secher
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·L M JolyJ F Dhainaut
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S M JakobJ Takala
Aug 18, 2001·Hypertension·M BucherA Kurtz
Jun 20, 2002·Critical Care Medicine·Miriam M TreggiariAnders Aneman
Apr 20, 2005·Acta Anaesthesiologica Scandinavica·F PortaS M Jakob
Jul 11, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dietmar TamandlPeter Goetzinger
Aug 29, 2009·Anesthesia and Analgesia·Doris Cunha-GoncalvesSten Blomquist
Feb 24, 2010·Critical Care : the Official Journal of the Critical Care Forum·Kevin C DoerschugAlix Ashare
Jun 5, 2010·Shock·Flavia R Machado, Bruno F Mazza

❮ Previous
Next ❯

Citations

Jul 16, 2014·Ultrasound in Medicine & Biology·Maria-Louisa IzamisMichalakis A Averkiou
Nov 12, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emily M BeseckerGregory M Holmes
Jul 14, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shengchen LiuStephan M Jakob
Jan 5, 2021·Current Opinion in Critical Care·Annika Reintam BlaserYaseen M Arabi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.