Effects of cardiovascular disease on pharmacokinetics

Cardiovascular Drugs and Therapy
V Rodighiero

Abstract

The pathophysiologic changes occurring in cardiovascular disease can affect the kinetics of drugs in several different ways. The present review examines these modifications and the underlying mechanisms. The kinetics of specific agents, such as antiarrhythmic, antihypertensive, cardiotonic, and other drugs are considered, and the clinical implications are outlined. The clinician should be aware of these modifications, because they require an adjustment of the dosage regimen. A rational basis for a correct therapeutic choice can be provided by adequate knowledge of these modifications.

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W S NimmoL F Prescott
Jan 3, 1977·European Journal of Clinical Pharmacology·D A RichardsL E Martin
Jun 1, 1975·Annals of Internal Medicine·C W ZwillichM M Weinberger
Nov 1, 1977·Clinical Pharmacology and Therapeutics·P du Souich, S Erill
May 1, 1978·Clinical Pharmacokinetics·N L Benowitz, W Meister
Mar 26, 1979·European Journal of Clinical Pharmacology·E E OhnhausE Nuesch
Jun 1, 1979·Clinical Pharmacology and Therapeutics·P JaillonT Blaschke
Jul 1, 1979·Clinical Pharmacology and Therapeutics·K F IlettJ D Woods
Nov 1, 1979·The American Journal of Cardiology·U R KorhonenJ T Takkunen
Nov 1, 1979·Clinical Pharmacology and Therapeutics·W S AronowJ Ferlinz
Dec 1, 1979·Clinical Pharmacology and Therapeutics·J DominicB Surawicz
Feb 1, 1978·Clinical Pharmacology and Therapeutics·C T Ueda, B S Dzindzio
May 25, 1978·The New England Journal of Medicine·R A Zito, P R Reid
Aug 1, 1978·Journal of Clinical Pharmacology·D LalkaD S Cannom
Jan 1, 1979·The American Journal of Cardiology·J J LimaW J Jusko
Mar 1, 1977·Clinical Pharmacology and Therapeutics·K M PiafskyR I Ogilvie
Jul 1, 1977·Clinical Pharmacology and Therapeutics·D E DrayerM M Reidenberg
Sep 1, 1977·American Heart Journal·R A ZitoJ A Longstreth
Aug 1, 1977·British Journal of Clinical Pharmacology·R L NationM Selig
Oct 10, 1975·European Journal of Clinical Pharmacology·F Hagemeijer
Mar 11, 1976·Clinical Pharmacology and Therapeutics·E G GiardinaE C Schreiber
Apr 17, 1976·British Medical Journal·L F PrescottR G Talbot
Feb 1, 1987·Journal of Cardiovascular Pharmacology·C H KleinbloesemD D Breimer
Jul 1, 1987·Clinical Pharmacology and Therapeutics·A A PiergiesA J Atkinson
Jan 15, 1988·The American Journal of Cardiology·R L Woosley, C Funck-Brentano
Jan 1, 1988·Journal of Cardiovascular Pharmacology·T Hedner, B Persson
Jan 1, 1988·European Journal of Clinical Pharmacology·B A van SchaikA J Porsius
Jan 1, 1985·European Journal of Clinical Pharmacology·E J SainsburyJ J Ashley
Feb 1, 1988·British Journal of Clinical Pharmacology·A K ScottW Bastain
Jan 1, 1988·European Journal of Clinical Pharmacology·E V SorensenW Bastain
Jan 1, 1986·British Journal of Clinical Pharmacology·J G KellyW D Cooper
Apr 1, 1986·British Journal of Clinical Pharmacology·N HockingsJ L Reid
Jun 1, 1987·Clinical Pharmacology and Therapeutics·K R Lees, J L Reid
Jan 31, 1986·The American Journal of Cardiology·R L WoosleyD M Roden
Apr 1, 1988·Clinical Pharmacology and Therapeutics·A J WilliamsJ Walls
Mar 1, 1988·Journal of Clinical Pharmacology·S C ForlandG J Conard
Jan 1, 1985·European Journal of Clinical Pharmacology·M Kurowski
Sep 1, 1988·British Journal of Clinical Pharmacology·P CromeJ Marley
Mar 1, 1988·Clinical Pharmacokinetics·R KirstenR Haerlin
Apr 1, 1988·Clinical Pharmacology and Therapeutics·J HungK F Ilett
Mar 1, 1988·British Journal of Clinical Pharmacology·M ScottT J Fitzsimons
Mar 1, 1988·British Journal of Clinical Pharmacology·D R RobertsonC F George
May 1, 1988·Journal of Clinical Pharmacology·O Grech-BélangerE LeBoeuf
Dec 1, 1987·Journal of Clinical Pharmacology·M D Ene, C J Roberts
Jan 1, 1987·European Journal of Clinical Pharmacology·P C WallerL E Ramsay
May 1, 1986·Clinical Pharmacokinetics·L A Siddoway, R L Woosley
Jan 1, 1987·European Journal of Clinical Pharmacology·B PerssonT Hedner
Aug 1, 1987·British Journal of Clinical Pharmacology·S C Montamat, D R Abernethy
Jan 1, 1986·European Journal of Clinical Pharmacology·P J PentikäinenL M Lampinen
Jul 1, 1986·Clinical Pharmacology and Therapeutics·C H KleinbloesemD D Breimer
Nov 1, 1986·Journal of Clinical Pharmacology·L M GutierrezM Fisher
Mar 1, 1985·Annals of Internal Medicine·M R VaskoD C Brater
Apr 1, 1985·Clinical Pharmacology and Therapeutics·J CussonS Lawand
May 1, 1985·Clinical Pharmacology and Therapeutics·C H KleinbloesemD D Breimer
Jan 1, 1985·European Journal of Clinical Pharmacology·P J PentikäinenG Wilen
Oct 1, 1985·The American Journal of Cardiology·J R BenottiJ S Alpert
Mar 28, 1974·The New England Journal of Medicine·K M KesslerM M Reidenberg
Jun 1, 1968·The American Journal of the Medical Sciences·J E DOHERTY
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein
Jul 6, 1971·Annals of the New York Academy of Sciences·J Koch-Weser
Jan 1, 1984·British Journal of Clinical Pharmacology·C I JohnstonD Casley
Mar 1, 1981·Journal of Cardiovascular Pharmacology·B SilkeS H Taylor
Jul 1, 1983·Journal of Cardiovascular Pharmacology·H R OchsD R Abernethy
Jul 1, 1982·Clinical Pharmacology and Therapeutics·R K FergusonP B Huber
Mar 1, 1984·British Journal of Clinical Pharmacology·C RicherJ F Giudicelli
Feb 27, 1984·The American Journal of Cardiology·G J Conard, R E Ober
Jan 1, 1983·European Journal of Clinical Pharmacology·U WiegersM Runge
Nov 1, 1983·Clinical Pharmacology and Therapeutics·S M MohiuddinJ W Reich
Jul 1, 1984·Clinical Pharmacokinetics·S VozehF Follath
Aug 1, 1984·Kidney International·D C BraterS Anderson
Nov 1, 1984·Clinical Pharmacokinetics·T H Grasela, L B Sheiner
Nov 2, 1983·Klinische Wochenschrift·H D KuntzB May
Jan 1, 1983·European Journal of Clinical Pharmacology·A HansonL A Wåhlander
Oct 1, 1982·British Journal of Clinical Pharmacology·C R KumanaM Gent
Dec 1, 1982·Clinical Pharmacology and Therapeutics·R J CodyG Williams
May 1, 1983·The American Journal of Cardiology·M S SmithE L Pritchett
Apr 1, 1983·British Journal of Clinical Pharmacology·B M DavidN S Stenhouse
Mar 1, 1982·British Journal of Clinical Pharmacology·A BarchowskyP A Routledge
Apr 1, 1982·Clinical Pharmacology and Therapeutics·L A BauerJ P Shea
Jan 1, 1982·Hypertension·P LarochelleJ Armstrong
Jan 1, 1982·Journal of Clinical Pharmacology·L A BauerR A Blouin
Aug 1, 1982·American Heart Journal·J B SchwartzD C Harrison
Jan 1, 1982·European Journal of Clinical Pharmacology·P AndersonC Sylvén
Aug 1, 1982·Kidney International·D C BraterP Chennavasin
Oct 1, 1982·Journal of Clinical Pharmacology·J R BenottiJ E McCue
Nov 1, 1980·Annals of Internal Medicine·P A RoutledgeD G Shand
Feb 1, 1981·European Journal of Clinical Pharmacology·K LandmarkJ P Amlie
Jun 1, 1981·Clinical Pharmacology and Therapeutics·J EdelsonE H Sonnenblick
Aug 1, 1981·Clinical Pharmacology and Therapeutics·P A RoutledgeW W Stargel
Oct 1, 1981·Clinical Pharmacology and Therapeutics·A GrahnénC von Bahr
Nov 1, 1981·Clinical Pharmacology and Therapeutics·S B FreedmanD T Kelly
Mar 1, 1980·The American Journal of Cardiology·M PackerM V Herman
Jul 1, 1980·Clinical Pharmacology and Therapeutics·N P ChauM E Safar
May 1, 1980·British Journal of Clinical Pharmacology·J PerezR I Ogilvie
Aug 1, 1980·Clinical Pharmacology and Therapeutics·D C BraterR Seiwell
Jun 1, 1980·European Journal of Clinical Pharmacology·R A BaughmanR L Williams
Oct 1, 1980·British Journal of Clinical Pharmacology·N D BaxH F Woods
Nov 1, 1956·Circulation·G W THOMSON
Oct 1, 1961·Archives of Internal Medicine·J E DOHERTYG K MITCHELL
Dec 1, 1974·British Journal of Clinical Pharmacology·E KarlssonF Sjöqvist

Related Concepts

Adrenergic beta-Agonists
Angiotensin-Converting Enzyme Inhibitors
Cardiac Depressants
Antihypertensive Agents
Calcium Channel Blockers
Cardiotonic Agents
Cardiovascular Diseases
Diuretic Effect

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.