Abstract
The purpose of this study was to compare long-term effects of cariporide with those of losartan in postinfarction heart failure. Female Sprague-Dawley rats with large myocardial infarctions and sham controls were randomized to losartan, cariporide, or placebo after 7 days and treated for 49 days. Cardiac function was assessed by echocardiography and measurement of left ventricular pressures, and gene expression was assessed by competitive reverse transcription-polymerase chain reaction. Cell dimensions, shortening, and relaxation were determined by videomicroscopy and calcium transients by fura 2. Losartan reduced postinfarction systolic and diastolic left ventricular dilation (by 24% and 31%, respectively), left and right ventricular weight (by 22% and 26%, respectively), and cardiomyocyte hypertrophy length and width (by 62% and 54%, respectively). Induction of myocardial atrial natriuretic peptide decreased 66%. Cariporide did not affect postinfarction hypertrophy or atrial natriuretic peptide. Losartan and cariporide respectively improved reduced cellular contractility (55% and 30%) and reduced elevated systolic (86% and 27%) and diastolic (49% and 43%) calcium. Losartan and cariporide respectively reduced prolonged time to...Continue Reading
References
Jun 1, 1991·The Journal of Physiology·J E FramptonM R Boyett
May 1, 1990·The Journal of Clinical Investigation·J K GwathmeyJ P Morgan
Sep 1, 1995·The American Journal of Physiology·X Q ZhangJ Y Cheung
Dec 3, 1993·Cell·J SadoshimaS Izumo
Jul 1, 1993·The Journal of Clinical Investigation·H ItoM Hiroe
Oct 10, 1997·Journal of Hypertension·M FleschM Böhm
Oct 12, 1999·Cardiology·S E LitwinP S Douglas
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H Yoshida, M Karmazyn
Mar 23, 2000·Cardiovascular Research·M JainF R Eberli
Mar 23, 2000·Cardiovascular Research·H SpitznagelT Unger
Mar 23, 2000·Cardiovascular Research·E CerbaiA Mugelli
May 23, 2000·Lancet·B PittB Thiyagarajan
Oct 18, 2000·Cardiovascular Research·S GuptaI S Anand
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K KusumotoM Karmazyn
Apr 11, 2001·Pflügers Archiv : European journal of physiology·C L CurlG Kotsanas
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J P LoennechenO Ellingsen
May 30, 2001·Cardiovascular Research·U WisløffO Ellingsen
Citations
Apr 6, 2005·Journal of Molecular and Cellular Cardiology·Mirna ChahineWolfgang Scholz
Feb 21, 2004·International Journal of Cardiology·Shoichi MiyamotoShun-ichi Tamaki
Jun 13, 2001·Journal of the American College of Cardiology·K M YeeA D Struthers
Jun 13, 2001·Journal of the American College of Cardiology·S MiyamotoS Sasayama
Sep 6, 2003·Journal of the American College of Cardiology·Fabiana RovedaCarlos Eduardo Negrão
Aug 24, 2002·Acta Physiologica Scandinavica·J P LoennechenØ Ellingsen
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Jinliang LiYouyi Zhang
Oct 24, 2006·Acta Physiologica·O J KemiØ Ellingsen
May 29, 2010·Circulation Research·Steve LancelWilson S Colucci
Oct 8, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Vidar BeisvagØyvind Ellingsen
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·María C Camilión de HurtadoHoracio E Cingolani
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Karmazyn Morris
Jul 2, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell, Jules C Hancox
Jan 3, 2016·Journal of Ethnopharmacology·Fredi CifuentesGlauco Morales
May 19, 2007·International Journal of Cardiology·Masahiro NomuraYutaka Nakaya
Mar 30, 2007·Regulatory Peptides·Øyvind HausoHelge L Waldum
Jul 5, 2015·Journal of Molecular and Cellular Cardiology·Marielle Scherrer-Crosbie
Aug 21, 2015·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Sep 10, 2005·British Journal of Pharmacology·Hartmut RuettenStefan Schaefer
Jul 9, 2004·British Journal of Pharmacology·Katrin RungwerthHartmut Ruetten
Feb 6, 2014·Acta Physiologica·S M KolsethM A Høydal
Mar 19, 2014·International Journal of Cardiology·Cui LiHongli Shan
Oct 11, 2017·Cardiovascular Research·Markus B SikkelKenneth T MacLeod
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
Jul 21, 2017·Canadian Journal of Physiology and Pharmacology·Ghassan Bkaily, Danielle Jacques
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ling ChenMorris Karmazyn
Jun 11, 2011·Journal of Cellular Physiology·Ole J KemiUlrik Wisloff