Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure

Circulation
J P LoennechenOyvind Ellingsen

Abstract

The purpose of this study was to compare long-term effects of cariporide with those of losartan in postinfarction heart failure. Female Sprague-Dawley rats with large myocardial infarctions and sham controls were randomized to losartan, cariporide, or placebo after 7 days and treated for 49 days. Cardiac function was assessed by echocardiography and measurement of left ventricular pressures, and gene expression was assessed by competitive reverse transcription-polymerase chain reaction. Cell dimensions, shortening, and relaxation were determined by videomicroscopy and calcium transients by fura 2. Losartan reduced postinfarction systolic and diastolic left ventricular dilation (by 24% and 31%, respectively), left and right ventricular weight (by 22% and 26%, respectively), and cardiomyocyte hypertrophy length and width (by 62% and 54%, respectively). Induction of myocardial atrial natriuretic peptide decreased 66%. Cariporide did not affect postinfarction hypertrophy or atrial natriuretic peptide. Losartan and cariporide respectively improved reduced cellular contractility (55% and 30%) and reduced elevated systolic (86% and 27%) and diastolic (49% and 43%) calcium. Losartan and cariporide respectively reduced prolonged time to...Continue Reading

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Citations

Apr 6, 2005·Journal of Molecular and Cellular Cardiology·Mirna ChahineWolfgang Scholz
Jun 13, 2001·Journal of the American College of Cardiology·S MiyamotoS Sasayama
Sep 6, 2003·Journal of the American College of Cardiology·Fabiana RovedaCarlos Eduardo Negrão
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Jul 5, 2015·Journal of Molecular and Cellular Cardiology·Marielle Scherrer-Crosbie
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Jul 21, 2017·Canadian Journal of Physiology and Pharmacology·Ghassan Bkaily, Danielle Jacques
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ling ChenMorris Karmazyn

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